IHB OpenIR
Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish
Yang, Bin-Yuan1,2; Zhai, Gang1; Gong, Yu-Long1,2; Su, Jing-Zhi1,2; Peng, Xu-Yan1,2; Shang, Guo-Hui1,2; Han, Dong1,3; Jin, Jun-Yan1; Liu, Hao-Kun1; Du, Zhen-Yu4; Yin, Zhan1; Xie, Shou-Qi1
2018-07-01
Source PublicationAMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
ISSN0193-1849
Volume315Issue:1Pages:E38-E51
AbstractInsulin, the most potent anabolic hormone, is critical for somatic growth and metabolism in vertebrates. Type 2 diabetes, which is the primary cause of hyperglycemia. results from an inability of insulin to signal glycolysis and gluconeogenesis. Our previous study showed that double knockout of insulin receptor a (insra) and b (insrb) caused beta-cell hyperplasia and lethality from 5 to 16 days postfertilization (dpf) (Yang BY, Zhai G, Gong YL, Su JZ, Han D, Yin Z, Xie SQ. Sci Bull (Beijing) 62: 486-492, 2017). In this study, we characterized the physiological roles of Insra and Insrb. in somatic growth and fueling metabolism, respectively. A high-carbohydrate diet was provided for insulin receptor knockout zebrafish from 60 to 120 dpf to investigate phenotype inducement and amplification. We observed hyperglycemia in both insra-/- fish and insrb-/- fish. Impaired growth hormone signaling, increased visceral adiposity, and fatty liver were detected in insrb-/- fish, which are phenotypes similar to the lipodystrophy observed in mammals. More importantly, significantly diminished protein levels of P-PPAR alpha, P-STATS, and IGF-1 were also observed in insrb-/- fish. In insra-/- fish, we observed increased protein content and decreased lipid content of the whole body. Taken together, although Insra and Insrb show overlapping roles in mediating glucose metabolism through the insulin-signaling pathway, Insrb is more prone to promoting lipid catabolism and protein synthesis through activation of the growth hormone-signaling pathway, whereas Insra primarily acts to promote lipid synthesis via glucose utilization.
SubtypeArticle
KeywordGh Signaling Hyperglycemia Insulin Receptors Lipid Metabolism
DOI10.1152/ajpendo.00227.2017
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05)
Language英语
WOS Research AreaEndocrinology & Metabolism ; Physiology
WOS SubjectEndocrinology & Metabolism ; Physiology
WOS KeywordFATTY LIVER-DISEASE ; I IGF-I ; GROWTH-HORMONE ; CELLULAR MECHANISMS ; SIGNALING PATHWAYS ; DIABETES-MELLITUS ; LIPID-METABOLISM ; GENE-EXPRESSION ; RESISTANCE ; PROTEIN
WOS IDWOS:000441172300005
PublisherAMER PHYSIOLOGICAL SOC
Funding OrganizationNational Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; National Basic Research Program of China(2014CB138602) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; Youth Innovation Promotion Association of Chinese Academy of Science(2013223) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; National Natural Science Foundation of China(31672670) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; Chinese Academy of Sciences(XDA08010405) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; China Agriculture Research System(CARS-46-18) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ05)
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/72763
Collection中科院水生所知识产出(2009年前)
Corresponding AuthorHan, Dong
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan, Hubei, Peoples R China
4.East China Normal Univ, Sch Life Sci, Lab Aquaculture Nutr & Environm Hlth, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Yang, Bin-Yuan,Zhai, Gang,Gong, Yu-Long,et al. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2018,315(1):E38-E51.
APA Yang, Bin-Yuan.,Zhai, Gang.,Gong, Yu-Long.,Su, Jing-Zhi.,Peng, Xu-Yan.,...&Xie, Shou-Qi.(2018).Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,315(1),E38-E51.
MLA Yang, Bin-Yuan,et al."Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 315.1(2018):E38-E51.
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