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Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III)
Li, Hongyan1,2; Xu, Wenjie1; Jin, Junyan1; Yang, Yunxia1; Zhu, Xiaoming1; Han, Dong1; Liu, Haokun1; Xie, Shouqi1
2018-11-01
Source PublicationAQUACULTURE
ISSN0044-8486
Volume496Pages:166-175
AbstractMany fish species experience natural periods of starvation; however, mobilization of energy sources may vary. To elucidate the mechanism underlying energy utilization and metabolic adaptation to food deprivation in gibel carp (Carassis auratus gibelio var. CAS III), fish (initial body weight 111.13 +/- 0.65 g) were starved for 0 d, 1 d, 2 d, 7 d, and 21 d, respectively. After seven days of food deprivation, plasma glucose levels significantly decreased, whereas plasma free fatty acids levels significantly increased. Liver glycogen levels in the group starved for 7 d significantly decreased, whereas muscle glycogen levels decreased in the group starved for 21 d, suggesting that glycogen in the liver is first utilized to provide energy than glycogen in the muscle. The transcriptional levels of glucose transporter type 2 (GLUT2) in the liver were upregulated during starvation. No changes in the mRNA levels of glycolytic enzymes such as glucokinase (GK) and 6-phosphofructokinase (6PFK) were observed in the liver. Gluconeogenic potential increased with starvation, possibly for blood glucose homeostasis, as indicated by the enhanced mRNA levels of gluconeogenic enzymes, including glucose-6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBPase), and phosphoenolpyruvate carboxykinase (PEPCK). The observation of a decrease in liver triglycerides content and the enhanced expression of hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) suggests the mobilization of lipid reserve in the liver. Enhanced fatty acid oxidation as indicated by the upregulated mRNA carnitine palmitoyl transferase 1 isoform a (CPT1a) and acyl-CoA oxidase 3 (ACO3) levels in the liver suggests that fatty acids are catabolized to provide energy during starvation. Sterol regulatory element binding protein 1 (SREBP1), ATP citrate lyase (ACLY), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS) were downregulated during starvation in both liver and muscle, indicating suppressed lipogenesis.
SubtypeArticle
KeywordStarvation Plasma Metabolites Glucose And Lipid Metabolism Gibel Carp
DOI10.1016/j.aquaculture.2018.07.015
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174) ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174) ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174) ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174)
Language英语
WOS Research AreaFisheries ; Marine & Freshwater Biology
WOS SubjectFisheries ; Marine & Freshwater Biology
WOS KeywordHORMONE-SENSITIVE LIPASE ; TROUT SALMO-GAIRDNERI ; RAINBOW-TROUT ; LIPOPROTEIN-LIPASE ; FOOD-DEPRIVATION ; BODY-COMPOSITION ; ATLANTIC COD ; NUTRITIONAL REGULATION ; PROLONGED STARVATION ; COMPENSATORY GROWTH
WOS IDWOS:000440660000020
PublisherELSEVIER SCIENCE BV
Funding OrganizationNational Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174) ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174) ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174) ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; 31672670 ; 31672670 ; 31672670 ; 31672670 ; 31602174) ; 31602174) ; 31602174) ; 31602174)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/72737
Collection中科院水生所知识产出(2009年前)
Corresponding AuthorJin, Junyan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Hongyan,Xu, Wenjie,Jin, Junyan,et al. Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III)[J]. AQUACULTURE,2018,496:166-175.
APA Li, Hongyan.,Xu, Wenjie.,Jin, Junyan.,Yang, Yunxia.,Zhu, Xiaoming.,...&Xie, Shouqi.(2018).Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III).AQUACULTURE,496,166-175.
MLA Li, Hongyan,et al."Effects of starvation on glucose and lipid metabolism in gibel carp (Carassius auratus gibelio var. CAS III)".AQUACULTURE 496(2018):166-175.
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