IHB OpenIR  > 淡水生态学研究中心
Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production
Li, Shun1,2; Lu, Long-Feng1; Li, Zhuo-Cong1,3; Zhang, Can1,3; Zhou, Xiao-Yu1,3; Zhou, Yu1,3; Zhang, Yong-An1,2,4
2019-01-15
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume202Issue:2Pages:559-566
AbstractIFN production is crucial for hosts to defend against viral infection, yet it must be tightly controlled to maintain immune homeostasis. TANK-binding kinase 1 (TBK1) is a pivotal kinase in the IFN induction signaling pathway, but it is negatively regulated by multiple molecules to avoid the excessive expression of IFN in mammals. However, the identified TBK1 suppressors and the mechanisms are rare in fish. In this study, we show that zebrafish major vault protein (MVP) recruits and degrades TBK1 in a lysosome-dependent manner to inhibit IFN production. Through viral infection, polyinosinic: polycytidylic acid and RIG-I-like receptor factor stimulation upregulated IFN expression, but overexpression of MVP significantly subverted these inductions. On the protein level, MVP interacted with TBK1, and interestingly, MVP recruited TBK1 from a uniformly distributed state in the cytoplasm to an aggregated state. Finally, MVP mediated the lysosome-dependent degradation of TBK1 and decreased the IFN response and IFN-stimulated genes expression. Our findings reveal that zebrafish MVP is a negative regulator of IFN production by restricting the activation of TBK1, supplying evidence of the balanced mechanisms of IFN expression in lower vertebrates.
SubtypeArticle
DOI10.4049/jimmunol.1801325
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31502200 ; National Natural Science Foundation of China(31502200 ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; 31802338 ; 31802338 ; 31725026) ; 31725026) ; National Natural Science Foundation of China(31502200 ; National Natural Science Foundation of China(31502200 ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; 31802338 ; 31802338 ; 31725026) ; 31725026)
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS KeywordPATTERN-RECOGNITION RECEPTORS ; I INTERFERON ; RIG-I ; PATHOGEN RECOGNITION ; ANTIVIRAL RESPONSE ; ADAPTER PROTEIN ; INDUCTION ; GENE ; ROLES ; BETA
WOS IDWOS:000455041800026
Funding OrganizationNational Natural Science Foundation of China(31502200 ; National Natural Science Foundation of China(31502200 ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; 31802338 ; 31802338 ; 31725026) ; 31725026) ; National Natural Science Foundation of China(31502200 ; National Natural Science Foundation of China(31502200 ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China(2018CFA011) ; 31802338 ; 31802338 ; 31725026) ; 31725026)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/67786
Collection淡水生态学研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan 43007, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Li, Shun,Lu, Long-Feng,Li, Zhuo-Cong,et al. Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production[J]. JOURNAL OF IMMUNOLOGY,2019,202(2):559-566.
APA Li, Shun.,Lu, Long-Feng.,Li, Zhuo-Cong.,Zhang, Can.,Zhou, Xiao-Yu.,...&Zhang, Yong-An.(2019).Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production.JOURNAL OF IMMUNOLOGY,202(2),559-566.
MLA Li, Shun,et al."Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production".JOURNAL OF IMMUNOLOGY 202.2(2019):559-566.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Shun]'s Articles
[Lu, Long-Feng]'s Articles
[Li, Zhuo-Cong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Shun]'s Articles
[Lu, Long-Feng]'s Articles
[Li, Zhuo-Cong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Shun]'s Articles
[Lu, Long-Feng]'s Articles
[Li, Zhuo-Cong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.