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题名: Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae
作者: Shi, Qipeng1, 2; Wang, Min1; Shi, Fengqiong3; Yang, Lihua1; Guo, Yongyong1; Feng, Chenglian4; Liu, Jingfu3; Zhou, Bingsheng1
关键词: Triphenyl phosphate ; Bioconcentration ; Developmental neurotoxicity ; Environmental risk ; Zebrafish embryos/larvae
刊名: AQUATIC TOXICOLOGY
发表日期: 2018-10-01
DOI: 10.1016/j.aquatox.2018.08.001
卷: 203, 页:80-87
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: Triphenyl phosphate (TPhP), a typical organophosphate ester, is frequently detected in the environment and biota samples. It has been implicated as a neurotoxin as its structure is similar to neurotoxic organophosphate pesticides. The purpose of the present study was to investigate its potential developmental neurotoxicity in fish by using zebrafish larvae as a model. Zebrafish (Danio rerio) embryos were exposed to 0.8, 4, 20 and 100 mu g/L of TPhP from 2 until 144 h post-fertilization. TPhP was found to have high bioconcentrations in zebrafish larvae after exposure. Further, it significantly reduced locomotor activity as well as the heart rate at the 100 mu g/L concentration. TPhP exposure significantly altered the content of the neurotransmitters gamma-aminobutyric and histamine. Downregulation of the genes related to central nervous system development (e.g., al-tubulin, mbp, syn2a, shha, and elavl3) as well as the corresponding proteins (e.g., al-tubulin, mbp, and syn2a) was observed, but the gap-43 protein was found to upregulated. Finally, marked inhibition of total acetylcholinesterase activity, which is considered as a biomarker of neurotoxicant exposure, was also observed in the larvae. Our results indicate that exposure to environmentally relevant concentrations of TPhP can affect different parameters related to center nervous system development, and thus contribute to developmental neurotoxicity in early developing zebrafish larvae.
关键词[WOS]: ORGANOPHOSPHORUS FLAME RETARDANTS ; TANDEM MASS-SPECTROMETRY ; DANIO-RERIO ; HUMAN EXPOSURE ; EXPRESSION ; CHROMATOGRAPHY ; PLASTICIZERS ; NEUROTRANSMITTER ; TOXICITY ; BIOACCUMULATION
语种: 英语
项目资助者: National Natural Science Foundation of China(21737005 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14040103) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ11) ; 41773085)
WOS记录号: WOS:000446147500009
ISSN号: 0166-445X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/56155
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
4.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China
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