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题名: Waterborne exposure to low concentrations of BDE-47 impedes early vascular development in zebrafish embryos/larvae
作者: Xing, Xiumei1; Kang, Jianmeng1; Qiu, Jiahuang; Zhong, Xiali1; Shi, Xiongjie2; Zhou, Bingsheng3; Wei, Yanhong1
关键词: Zebrafish ; Polybrominated diphenyl ethers ; Brominated flame retardants ; Early exposure ; Developmental toxicity ; Vascular toxicity
刊名: AQUATIC TOXICOLOGY
发表日期: 2018-10-01
DOI: 10.1016/j.aquatox.2018.07.012
卷: 203, 页:19-27
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: Polybrominated diphenyl ethers (PBDEs) are persistent flame retardants ubiquitously existing in various environment matrices. In spite of a recent reduction in use according to the phase-out policy, high levels of PBDEs are still found in both environmental and biological samples due to their persistent property and large-scale production over a long history. Developmental toxicity is a major health concern of PBDEs. However, the impact of PBDE exposure on vascular development remains poorly understood. In this study, we investigated the effect of low concentrations of 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), a predominant PBDE congener, in environmental matrices and biota, on early vascular development using zebrafish. Zebrafish embryos were continuously exposed to waterborne BDE-47 at 0.06, 0.2, 0.6 mu M starting from 2 h post-fertilization (hpf). Fluorescent images of vasculatures in Tg(kdrl:eGFP) zebrafish were acquired using a confocal microscope. The results indicated that BDE-47 exposure had no effect on hatching rate, survival, body weight, body length or heart rate in the early stage within 72 hpf, whereas zebrafish exposed to BDE-47 exhibited impairments in the growth of multiple types of blood vessels. The percentage of completed intersegmental vessels (ISV) at 30 hpf decreased in embryos treated with BDE-47 in a dose-dependent fashion. BDE-47 exposure led to a slight decrease in the growth of common cardinal vein (CCV), while dramatically hindered CCV remodeling process reflected by the larger CCV area and wider ventral diameter. BDE-47 exposure significantly reduced sub-intestinal vessels (SIV) area as well as the vascularized yolk area in zebrafish larvae at 72 hpf. In addition, the expression of genes related to vascular growth and remodeling was markedly suppressed in BDE-47-exposed zebrafish. These findings demonstrate the adverse effects of BDE-47 on early vascular development, and confirm the vascular toxicity of PBDEs in vivo. The results indicate that developing vasculature in zebrafish is sensitive to BDE-47 exposure, and may serve as a powerful tool for the assessment of early exposure to PBDEs.
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; EMBRYONIC EXPOSURE ; FLAME-RETARDANTS ; DANIO-RERIO ; BREAST-MILK ; VEGF ; ANGIOGENESIS ; LARVAE ; PBDES ; ENVIRONMENT
语种: 英语
项目资助者: National Natural Science Foundation of China(21777199 ; National Key R & D program of China(2017YFC1600205) ; 100 Top Talents Program of Sun Yat-sen University ; 81402715)
WOS记录号: WOS:000446147500003
ISSN号: 0166-445X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/56149
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Sch Publ Hlth, Dept Toxicol, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China
2.Wuhan Univ, Inst Adv Studies, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
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