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题名: Effects of glucose administration on glucose and lipid metabolism in two strains of gibel carp (Carassius gibelio)
作者: Jin, Junyan1; Yang, Yunxia1; Zhu, Xiaoming1; Han, Dong1; Liu, Haokun1; Xie, Shouqi1
关键词: Glucose injection ; Liver ; Muscle ; Genotype ; A strain ; DT strain
刊名: GENERAL AND COMPARATIVE ENDOCRINOLOGY
发表日期: 2018-10-01
DOI: 10.1016/j.ygcen.2018.05.023
卷: 267, 页:18-28
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: We compared the glucose clearance ability of gibel carp CAS III (A strain) with gibel carp Dongting (DT strain). A previous study suggested that these two strains responded to insulin differently. As insulin plays an important role in glucose utilization, we hypothesized that the ability to eliminate excess glucose after a glucose load would differ between A strain and DT strain. To test this hypothesis, fasted specimens of both strains of gibel carp were injected with glucose. As expected, glucose induced hyperglycemia in both A strain and DT strain. In both strains, mRNA levels of the glycolytic enzyme 6-phosphofructokinase (6PFK) increased in the white skeletal muscle 8 h post-injection, while expression levels of glucose-6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBPase), and phosphoenolpyruvate carboxykinase (PEPCK) decreased in the liver 8 h post-injection. In the DT strain, both GLUT4 expression and muscular glycolytic processes increased, as reflected by elevated hexokinase 2 (HK2) and pyruvate kinase (PK) mRNA expression levels. The DT strain also returned to basal glycemia more quickly than the A strain (within 6 h versus more than 12 h). The glycogen concentration in the liver of the DT strain was higher than that of the A strain, indicating that the DT strain was better able to store glucose as glycogen than the A strain. Overall, the DT strain was better able to clear excess blood glucose after the glucose tolerance test than the A strain.
关键词[WOS]: TROUT ONCORHYNCHUS-MYKISS ; DIETARY CARBOHYDRATE UTILIZATION ; BASS DICENTRARCHUS-LABRAX ; SEABREAM SPARUS-AURATA ; MUSCLE FAT-CONTENT ; RAINBOW-TROUT ; GENE-EXPRESSION ; NUTRITIONAL REGULATION ; GILTHEAD SEABREAM ; COMMON CARP
语种: 英语
项目资助者: National Natural Science Foundation of China(31101908 ; China Agriculture Research System(CARS-45-09) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA08010405) ; Knowledge Innovation Program of the Chinese Academy of Sciences ; 31672670 ; 31602174)
WOS记录号: WOS:000444366400003
ISSN号: 0016-6480
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/56141
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
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