Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates
Zhang, Xu-Jie1,2,3; Zhang, Xiang-Yang4,5; Wang, Peng4,5; Zhang, Yong-An1,2,3
2018-12-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume89Issue:1Pages:73-82
AbstractIn mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other teleost fish, suggesting that CD80 and CD86 arose by gene duplication in the tetrapod branch, after the separation of fish and tetrapods. However, in this study, another CD80/86 gene has been cloned from rainbow trout, termed rtCD80/86B. The sequence identity between trout CD80/86 is significantly higher than that between CD80 and CD86 in tetrapods, indicating that CD80 and CD86 underwent divergent evolution in vertebrates, especially in tetrapods. Gene synteny analyses showed that the CD80 and CD86 genes are closely located in the same chromosome in tetrapods. However, CD80/86 genes are located in two distinct chromosomes in rainbow trout and Atlantic salmon, suggesting that salmonid CD80/86 genes arose by the salmonid-specific whole-genome duplication (WGD) event. Expression analysis showed that rtCD80/86A was more abundant and inducible than rtCD80/86B in various tissues, indicating the important role of rtCD80/86A in trout immunity. Interestingly, we found that head kidney B cells showed higher expression level of rtCD80/86A and rtCD80/86B when compared with the other leukocytes, suggesting a potential role for trout B cells as antigen-presenting cells (APCs).
SubtypeArticle
KeywordCd80/86 Duplication Evolution Rainbow Trout
DOI10.1016/j.dci.2018.08.007
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31602184) ; National Natural Science Foundation of China(31602184)
Language英语
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS KeywordGENOME PROVIDES INSIGHTS ; PRIMITIVE TELEOST FISH ; B7 FAMILY ; COSTIMULATORY MOLECULE ; ONCORHYNCHUS-MYKISS ; TISSUE DISTRIBUTION ; EXPRESSION ; CD28 ; LIGANDS ; RECEPTORS
WOS IDWOS:000444932200009
Funding OrganizationNational Natural Science Foundation of China(31602184) ; National Natural Science Foundation of China(31602184)
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/56133
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Wuhan, Hubei, Peoples R China
2.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xu-Jie,Zhang, Xiang-Yang,Wang, Peng,et al. Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,89(1):73-82.
APA Zhang, Xu-Jie,Zhang, Xiang-Yang,Wang, Peng,&Zhang, Yong-An.(2018).Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,89(1),73-82.
MLA Zhang, Xu-Jie,et al."Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 89.1(2018):73-82.
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