Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver
Wu, Nan1,2,3; Wang, Biao1; Cui, Zheng-Wei1,4; Zhang, Xiang-Yang1,4; Cheng, Ying-Yin1; Xu, Xuan5; Li, Xian-Mei1,4; Wang, Zhao-Xi1,4; Chen, Dan-Dan1,2,3; Zhang, Yong-An1,2,3
2018-09-10
Source PublicationFRONTIERS IN PHYSIOLOGY
ISSN1664-042X
Volume9Issue:1154Pages:1-20
AbstractIn aquafeeds, fish-meal has been commonly replaced with plant protein, which often causes enteritis. Currently, foodborne enteritis has few solutions in regards to prevention or cures. The recovery mechanism from enteritis in herbivorous fish may further help understand prevention or therapy. However, few reports could be found regarding the recovery or resilience to fish foodborne enteritis. In this study, grass carp was used as an animal model for soybean meal induced enteritis and it was found that the fish could adapt to the soybeanmeal at a moderate level of substitution. Resilience to soybeanmeal stress was found in the 40% soybean meal group for juvenile fish at growth performance, morphological and gene expression levels, after a 7-week feeding trial. Furthermore, the intestinal transcriptomic data, including transcriptome and miRNAome, was applied to demonstrate resilience mechanisms. The result of this study revealed that in juvenile grass carp after a 7-week feeding cycle with 40% soybean meal, the intestine recovered via enhancing both an immune tolerance and wound healing, the liver gradually adapted via re-balancing immune responses, such as phagosome and complement cascades. Also, many immune factors in the gut and liver were systemically revealed among stages of on-setting, remising, and recovering (or relief). In addition, miRNA regulation played a key role in switching immune states. Thus, the present data systemically demonstrated that the molecular adaptation mechanism of fish gut-liver immunity is involved in the resilience to soybean meal stress.
SubtypeArticle
KeywordSoybean Meal Induced Enteritis Resilience Transcriptome Mirnaome Gut-liver Immunity Grass Carp
DOI10.3389/fphys.2018.01154
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Basic Research Program of China(2014CB138601) ; National Natural Science Foundation of China(31472307) ; Knowledge Innovation Program of the Chinese Academy of Sciences ; National Basic Research Program of China(2014CB138601) ; National Natural Science Foundation of China(31472307) ; Knowledge Innovation Program of the Chinese Academy of Sciences
Language英语
WOS Research AreaPhysiology
WOS SubjectPhysiology
WOS KeywordSALMO-SALAR L. ; PROLIFERATOR-ACTIVATED RECEPTOR ; CARP CTENOPHARYNGODON-IDELLA ; INFLAMMATORY-BOWEL-DISEASE ; ATLANTIC SALMON ; T-CELLS ; GRASS CARP ; INTERLEUKIN-7 RECEPTOR ; ULCERATIVE-COLITIS ; DISTAL INTESTINE
WOS IDWOS:000444152800001
Funding OrganizationNational Basic Research Program of China(2014CB138601) ; National Natural Science Foundation of China(31472307) ; Knowledge Innovation Program of the Chinese Academy of Sciences ; National Basic Research Program of China(2014CB138601) ; National Natural Science Foundation of China(31472307) ; Knowledge Innovation Program of the Chinese Academy of Sciences
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/56125
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China
4.Univ Chinese Acad Sci, Coll Modern Agr Sci, Beijing, Peoples R China
5.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Wu, Nan,Wang, Biao,Cui, Zheng-Wei,et al. Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver[J]. FRONTIERS IN PHYSIOLOGY,2018,9(1154):1-20.
APA Wu, Nan.,Wang, Biao.,Cui, Zheng-Wei.,Zhang, Xiang-Yang.,Cheng, Ying-Yin.,...&Zhang, Yong-An.(2018).Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver.FRONTIERS IN PHYSIOLOGY,9(1154),1-20.
MLA Wu, Nan,et al."Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver".FRONTIERS IN PHYSIOLOGY 9.1154(2018):1-20.
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