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Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification
Zhang, Weicheng1,2; Huang, Jiaolong2,3; Liang, Lei2,3; Yao, Lunguang1; Fang, Tao2,3
2019
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume214Pages:754-763
AbstractCytotoxicity of silver nanoparticles (Ag NPs) is attributed to silver internalization, which can be depressed by dissolved organic matter (DOM) to form Ag-DOM. Ag-DOM are bioavailable and then silver internalization could be increased. Herein, 3 and 48-h Escherichia coli viability bioassays were employed to evaluate effect of fulvic acid and humic acid (10 mg L-1) on cytotoxicity of 30 and 100 nm PVP-Ag NPs. Moreover, zebrafish embryos were used as reference model to understand silver internalization routes. Ag ions or Ag-DOM internalization varied in routes to Escherichia coli and zebrafish embryos. Cytotoxicity mechanisms of PVP-Ag NPs are dynamic. In 3-h bioassays, cytotoxicity of PVP-Ag NPs mainly involves Ag particle-related toxicity. DOM significantly mitigated cytotoxicity of PVP-Ag NPs (p < 0.05) through adhering on surface of PVP-Ag NPs. Ag ions or Ag-DOM were hardly internalized into Escherichia coli cells during 3-h exposures duration. In 48-h bioassays, cytotoxicity of PVP-Ag NPs is dependent on Ag ion related and particle-related toxicity. Silver was internalized into Escherichia coli via Ag-DOM consumption as an indirect route. Thus, DOM promoted silver internalization into Escherichia coli but not into zebrafish embryos, significantly intensifying cytotoxicity (p < 0.05). The results suggested DOM has a dual impact on cytotoxicity of PVP-Ag NPs: mitigation and intensification. For risk assessment, it should be considered that cytotoxicity mechanisms of PVP-Ag NPs are dynamic and threats can be intensified by DOM during prolonged exposure. (C) 2018 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordDual Impact Dissolved Organic Matter Cytotoxicity Pvp-ag Nps Escherichia Coli
DOI10.1016/j.chemosphere.2018.09.179
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(21477159) ; National Natural Science Foundation of China(21477159) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454) ; National Natural Science Foundation of China(21477159) ; National Natural Science Foundation of China(21477159) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454)
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS KeywordNANO-SPECIFIC TOXICITY ; SILVER NANOPARTICLES ; ANTIBACTERIAL ACTIVITY ; ZNO NANOPARTICLES ; HUMIC-ACID ; PARTICLE ; AGGREGATION ; DISSOLUTION ; STABILITY ; ION
WOS IDWOS:000449891300082
Funding OrganizationNational Natural Science Foundation of China(21477159) ; National Natural Science Foundation of China(21477159) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454) ; National Natural Science Foundation of China(21477159) ; National Natural Science Foundation of China(21477159) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; Scientific Research and Service Platform Fund of Henan Province(2016151) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454) ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province(17454)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/56061
Collection水环境工程研究中心
Affiliation1.Nanyang Normal Univ, Coll Agr Engn, Collaborat Innovat Ctr Water Secur Water Source R, South To North Div Project Henan Prov, Nanyang 473061, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Weicheng,Huang, Jiaolong,Liang, Lei,et al. Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification[J]. CHEMOSPHERE,2019,214:754-763.
APA Zhang, Weicheng,Huang, Jiaolong,Liang, Lei,Yao, Lunguang,&Fang, Tao.(2019).Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification.CHEMOSPHERE,214,754-763.
MLA Zhang, Weicheng,et al."Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification".CHEMOSPHERE 214(2019):754-763.
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