中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水环境工程研究中心  > 期刊论文
题名: Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring
作者: Guo, Yongyong1; Chen, Lianguo1; Wu, Juan1; Hua, Jianghuan1; Yang, Lihua1; Wang, Qiangwei2; Zhang, Wei3; Lee, Jae-Seong4; Zhou, Bingsheng1
关键词: Bisphenol A ; n-TiO2 ; Chronic co-exposure ; Maternal transfer ; Developmental neurotoxity and thyroid ; disruption ; Zebrafish
刊名: SCIENCE OF THE TOTAL ENVIRONMENT
发表日期: 2019-02-10
DOI: 10.1016/j.scitotenv.2018.09.007
卷: 650, 页:557-565
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: The coexistence of organic toxicants and nanoparticles in the environment influences pollutant bioavailability and toxicity. Using chronic co-exposure to an adult zebrafish model, this study investigated the transfer kinetics and transgenerational effects of bisphenol A (BPA) and titanium dioxide nanoparticles (n-TiO2) exposure in F1 offspring. When single and combined exposure to BPA (0, 2, and 20 mu g/L) and n-TiO2 (100 mu g/L) were compared, combined exposure was found to reciprocally facilitate bioaccumulation in adult fish while enhancing maternal transfer to offspring. Thyroid endocrine disruption and developmental neuroloxiciLy were observed in larval offspring by parental exposure to BPA alone or in combination with n-TiO2. Exposure to 20 mu g/L BPA significantly decreased the thyroxine (T4) concentration in adult plasma, leading to less transfer info the eggs. The presence of 20 mu g/L BPA with n-TiO2 further decreased the level of T4 compared lo BPA exposure alone. Additionally, offspring larvae derived from exposed parents exhibited lethargic swimming behavior. Overall, this study examined the interactions of BPA and n-TiO2 with regard lo their bioaccumulation, maternal transfer, and developmental effects, which highlighted that co-exposure dynamics are important and need to be considered for accurate environmental risk assessment. (C) 2018 Elsevier B.V. All rights reserved.
关键词[WOS]: TITANIUM-DIOXIDE NANOPARTICLES ; DIPHENYL ETHERS PBDES ; GENE-EXPRESSION ; IN-VITRO ; MARINE BIVALVE ; HUMAN HEALTH ; DANIO-RERIO ; RAT-BRAIN ; EXPOSURE ; LARVAE
语种: 英语
项目资助者: National Natural Science Foundation of China(21577168) ; Chinese Academy of Sciences(XDB14040103) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ11)
WOS记录号: WOS:000447092700057
ISSN号: 0048-9697
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/56034
Appears in Collections:水环境工程研究中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China
3.East China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China
4.Sungkyunkwan Univ, Dept Biol Sci, Coll Sci, Suwon 16419, South Korea
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guo, Yongyong]'s Articles
[Chen, Lianguo]'s Articles
[Wu, Juan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guo, Yongyong]‘s Articles
[Chen, Lianguo]‘s Articles
[Wu, Juan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2019  中国科学院水生生物研究所 - Feedback
Powered by CSpace