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题名: Health risks associated with genetic alterations in internal clock system by external factors
作者: Khan, Suliman1, 2, 3; Nabi, Ghulam1, 3; Yao, Lunguang2; Siddique, Rabeea4, 5; Sajjad, Wasim3, 6; Kumar, Sunjeet1; Duan, Pengfei2; Hou, Hongwei1
关键词: Circadian system ; sleep ; health risks ; clock genes
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
发表日期: 2018
DOI: 10.7150/ijbs.23744
卷: 14, 期:7, 页:791-798
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ; Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
英文摘要: The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep.
关键词[WOS]: GLUCOSE-METABOLISM IMPLICATIONS ; SLEEP-PHASE SYNDROME ; CIRCADIAN CLOCK ; SHIFT-WORK ; THERAPEUTIC IMPLICATIONS ; MOLECULAR-COMPONENTS ; LIGHT EXPOSURE ; FOOD-INTAKE ; JET-LAG ; DISORDER
语种: 英语
项目资助者: Scientific research and service platform fund of Henan Province(2016151) ; fund of scientific and technological innovation team of water ecological security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province(17454) ; CAS-TWAS president's fellowship
WOS记录号: WOS:000433261800010
ISSN号: 1449-2288
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50893
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
2.Nanyang Normal Univ, Henan Key Lab Ecol Secur Water Source Reg Mid Lin, Collaborat Innovat Ctr Water Secur Water Source R, Nanyang, Henan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Huazhong Univ Sci & Technol, Adv Biomat & Tissue Engn Ctr, Wuhan 430074, Hubei, Peoples R China
5.Huazhong Univ Sci & Technol, Dept Biomed Engn, Wuhan 430074, Hubei, Peoples R China
6.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Petr Resources, Gansu Prov Key Lab Petr Resources Res, Lanzhou 730000, Gansu, Peoples R China
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