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题名: Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi
作者: Laghari, Zubair Ahmed1; Chen, Shan Nan1; Li, Li1; Huang, Bei1; Gan, Zhen1; Zhou, Ying1; Huo, Hui Jun1; Hou, Jing1; Nie, Pin1, 2, 3, 4
关键词: Type I IFN ; Cytokine receptor family B ; CRFB ; STAT1 ; STAT2 ; IRF3 ; IRF7 ; Teleost fish
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2018-07-01
DOI: 10.1016/j.dci.2018.02.008
卷: 84, 页:94-108
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Immunology ; Zoology
研究领域[WOS]: Fisheries ; Immunology ; Zoology
英文摘要: Teleost fish are unique in having type I and type II interferons (IFNs) only, and the type I IFNs are classified into Group one and Group two based on the presence of two or four cysteines respectively, and are further classified into seven subgroups. In the present study, three distinct type I IFNs, IFNc, IFNd and IFNh, have been identified in the genome sequences of a perciform fish, the mandarin fish Siniperca chuatsi. These IFNs are induced following the stimulation of Polyinosinic polycytidylic acid (poly(I: C)) and Resiquimod (R848) either in vivo or in vitro. But, the infectious spleen and kidney necrosis virus (ISKNV) infection caused a delayed response of IFNs, which may be resulted from the viral inhibition of type I IFN production and related signalling. The three receptor subunits, cytokine receptor family B 1 (CRFB1), CRFB2 and CRFB5 are also expressed in a similar manner as observed for the IFNs, and IFNc, IFNd and IFNh use preferentially the receptor complex, CRFB2 and CRFB5, CRFB1 and CRFB5, CRFB1 and CRFB5 respectively for their effective signalling in the induction of IFN-stimulated genes (ISGs). Moreover, the IFNs are able to induce their own expression, and also the IRF3 and IRF7 expression, leading to the amplification of IFN cascade. It is further revealed that these three IFNs are transcribed differently by IRF7 and IRF3. The composition, function, signalling and transcription of type I IFNs have been investigated in detail in a teleost fish. (C) 2018 Elsevier Ltd. All rights reserved.
关键词[WOS]: KIDNEY NECROSIS VIRUS ; INTERFERON REGULATORY FACTOR-3 ; CROAKER LARIMICHTHYS-CROCEA ; INFECTIOUS SPLEEN ; ATLANTIC SALMON ; PARALICHTHYS-OLIVACEUS ; JAPANESE FLOUNDER ; ANTIVIRAL ACTIVITY ; ORYZIAS-LATIPES ; GENE-EXPRESSION
语种: 英语
项目资助者: National Natural Science Foundation of China(31230075) ; China Agriculture Research System(CARS-46) ; special top talent plan "One Thing One Decision (Yishiyiyi) in Shandong Province, China ; "Strengthening and Development of Sindh Agriculture University Tandojam" Phase-I Programme in Pakistan ; University of Chinese Academy of Sciences ; Institute of Hydrobiology, Chinese Academy of Sciences through the State Key Laboratory of Freshwater Ecology and Biotechnology
WOS记录号: WOS:000431160800009
ISSN号: 0145-305X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50860
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Hubei, Peoples R China
4.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
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