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题名: Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtgl) mRNA expression
作者: Chen, Minjie1, 2; Zhang, Jie2; Pang, Shaochen3; Wang, Chang3; Wang, Ling3; Sun, Yonghua4; Song, Maoyong5; Liang, Yong1, 3
关键词: Zebrafish embryo ; Vitellogenin 1 ; Estrogenic effect ; Endocrine disrupting chemicals
刊名: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
发表日期: 2018
DOI: 10.1016/j.chpc.2017.11.010
卷: 204, 页:45-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
英文摘要: By measuring the vitellogenin 1 (vtgl) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17 beta-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect Of the tested chemicals was ranked as: DES > E-2 > E-3 > OP > BPA, which is consistent with various in vivo and in vitro models. Therefore, the measurement of vtgl gene expression in zebrafish embryos would be a valuable method for screening EDCs including both environmental estrogens and anti-estrogens.
关键词[WOS]: BISPHENOL-A ; ENVIRONMENTAL ESTROGENS ; IN-VIVO ; HEPATOCYTES ; EXPOSURE ; ASSAYS ; DIETHYLSTILBESTROL ; TAMOXIFEN ; BIOMARKER ; RECEPTOR
语种: 英语
项目资助者: National Natural Science Foundation of China(21477049) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030501) ; State Key Laboratory of Freshwater Ecology and Biotechnology(2014FB07)
WOS记录号: WOS:000424182100005
ISSN号: 1532-0456
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50698
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Jianghan Univ, Sch Med, Wuhan 430056, Hubei, Peoples R China
2.Huazhong Agr Univ, Coll Resources & Environm, Wuhan 430070, Hubei, Peoples R China
3.Jianghan Univ, Inst Environm Hlth, Wuhan 430056, Hubei, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
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