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题名: Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae
作者: Zhu, Biran1, 2; Zhao, Gang2; Yang, Lihua1; Zhou, Bingsheng1
关键词: Tetrabromobisphenol A (TBBPA) ; Zebrafish (Danio rerio) ; Thyroid disruption ; Neurodevelopmental toxicity
刊名: CHEMOSPHERE
发表日期: 2018-04-01
DOI: 10.1016/j.chemosphere.2018.01.080
卷: 197, 页:353-361
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: Tetrabromobisphenol A (TBBPA), one of the most widely used brominated flame retardants (BFRs), has resulted in worldwide environmental contamination. TBBPA has been reported as a thyroid endocrine disruptor and a potential neurotoxicant. However, the underlying mechanism is still not clear. In this study, zebrafish (Danio rerio) embryos (2 h post-fertilization, hpf) were exposed to different concentrations of TBBPA (50, 100, 200 and 400 mu g/L) alone or in combination with 3,3',5-triiodo-l-thyronine (T3, 20 TBBPA, 200 mu g/L). The results confirmed that TBBPA could evoke thyroid disruption by observations of increased T4 contents and decreased T3 contents, accompanied by up-regulated tsh beta, tg mRNA and down-regulated ttr and tr beta mRNA levels in zebafish larvae. TBBPA-induced neuro-developmental toxicity was also indicated by down-regulated transcription of genes related to central nervous system (CNS) development (e.g., alpha l-tubulin, mbp and shha), and decreased locomotor activity and average swimming speed. Our results further demonstrated that treatment with T3 could reverse or eliminate TBBPA-induced effects on thyroidal and neurodevelopmental parameters. Given the above, we hypothesize that the observed neurodevelopmental toxicity in the present study could be attributed to the thyroid hormone disruptions by TBBPA. (C) 2018 Elsevier Ltd. All rights reserved.
关键词[WOS]: DECABROMODIPHENYL ETHER BDE-209 ; BROMINATED FLAME RETARDANTS ; DANIO-RERIO ; A TBBPA ; EXPOSURE ; EXPRESSION ; RECEPTOR ; LEAD ; AXIS ; BIOCONCENTRATION
语种: 英语
项目资助者: National Natural Science Foundation of China(21737005 ; Young Plan from Hubei University of Traditional Chinese Medicine(2016ZZX003) ; Educational Commission of Hubei Province of China(Q20161011) ; 21307153)
WOS记录号: WOS:000426231900040
ISSN号: 0045-6535
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50693
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Hubei Univ Chinese Med, Dept Basic Med, Wuhan 430065, Hubei, Peoples R China
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