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题名: Dysregulation of Intestinal Health by Environmental Pollutants: Involvement of the Estrogen Receptor and Aryl Hydrocarbon Receptor
作者: Chen, Lianguo1, 2; Zhang, Weipeng3; Hua, Jianghuan2; Hu, Chenyan4; Lai, Nelson Lok-Shun1; Jan, Pei-Yuan3; Lam, Paul K. S.1; Lam, James C. W.1, 5; Zhou, Bingsheng2
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2018-02-20
DOI: 10.1021/acs.est.7b06322
卷: 52, 期:4, 页:2323-2330
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Technology ; Life Sciences & Biomedicine
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
英文摘要: To determine how environmental pollutants induce dysbiosis of the gut microbiota, we exposed adult zebrafish to model pollutants with varied modes of action (atrazine, estradiol, polychlorinated biphenyl [PCB]126, and PCB153) for 7 days. Subsequently, metagenomic sequencing of the intestines was performed to compare the gut microbiomes among the groups. We observed clear compound- and sex-specific responses to xenobiotic stress. Principal component analysis revealed involvement of the aryl hydrocarbon receptor (AhR) and, to a lesser extent, the estrogen receptor (ER) in the dysregulation of the intestinal microbiota. The model pollutants differentially impaired intestinal and hepatic physiological activities, as indicated by assessments of gut motility, epithelial permeability, inflammation, and oxidative stress. Correlation analysis showed that abnormal Aeromonas reproduction, especially in the PCB126 groups, was significantly positively associated with oxidative damage. Aeromonas closely interacted with Mannheimia and Blastococcus to regulate intestinal permeability. In summary, we demonstrated that ER and AhR signaling regulated the dynamics of the gut microbiota. Our findings provide new mechanistic insight into the complex interactions between the host metabolism and gut microbiota, which may contribute to the grouped assessment of environmental pollutants in future.
关键词[WOS]: GUT MICROBIOTA DYSBIOSIS ; ZEBRAFISH LARVAE ; BISPHENOL-A ; EXPOSURE ; MICE ; METABOLISM ; ALPHA ; DISRUPTION ; REVEALS ; OBESITY
语种: 英语
项目资助者: Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14040103) ; National Natural Science Foundation of China(21737005)
WOS记录号: WOS:000426143300071
ISSN号: 0013-936X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50673
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
4.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Peoples R China
5.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Hong Kong, Peoples R China
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