中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水环境工程研究中心  > 期刊论文
题名: Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish
作者: Chen, Lianguo1, 2; Guo, Yongyong2; Hu, Chenyan3; Lam, Paul K. S.1; Lam, James C. W.1, 4; Zhou, Bingsheng2
关键词: Gut microbiota ; Titanium dioxide nanoparticles ; Bisphenol A ; Combined toxicity ; Zebrafish health
刊名: ENVIRONMENTAL POLLUTION
发表日期: 2018-03-01
DOI: 10.1016/j.envpol.2017.11.074
卷: 234, 页:307-317
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: Gut microbiota is of critical relevance to host health. However, toxicological understanding of environmental pollutants on gut microbiota is limited, not to mention their combined effects. In the present study, adult zebrafish (Danio rerio) were exposed to titanium dioxide nanoparticles (nano-TiO2; 100 mu g/L), bisphenol A (BPA; 0, 2, and 20 mu g/L) or their binary mixtures for three months. Sequencing of 16S rRNA amplicons found that nano-TiO2 and BPA coexposure shifted the intestinal microbial community, interacting in an antagonistic manner when the BPA concentration was low but in a synergistic manner at a higher BPA concentration. Sex-and concentration-dependent responses to the coexposure regime were also observed for zebrafish growth and intestinal health (e.g. neurotransmission, epithelial barrier permeability, inflammation, and oxidative stress). Correlation analysis showed that oxidative stress after nano-TiO2 and BPA coexposure was tightly associated with the imbalanced ratio of pathogenic Lawsonia and normal metabolic Hyphomicrobium, where higher abundance of Lawsonia but lower abundance of Hyphomicrobium were induced concurrently. A positive relationship was observed between zebrafish body weight and the abundance of Bacteroides in the gut, which was also closely associated with the genera of Anaerococcus, Finegoldia, and Peptoniphilus. This study revealed, for the first time, the combined effects of nano-TiO2 and BPA coexposure on the dynamics of the gut microbiome, which proved to have toxicological implications for zebrafish host health. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: TIO2 NANOPARTICLES ; MARINE BIVALVE ; TOXICITY ; EXPOSURE ; LARVAE ; BIOCONCENTRATION ; NANOMATERIALS ; METABOLISM ; OBESITY ; IMPACT
语种: 英语
项目资助者: National Natural Science Foundation of China(21577168 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14040103) ; 21237005)
WOS记录号: WOS:000426225100032
ISSN号: 0269-7491
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50672
Appears in Collections:水环境工程研究中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China
4.Educ Univ Hong Kong, Dept Sci & Environm Studies, 10 Lo Ping Rd, Tai Po, Hong Kong, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Lianguo]'s Articles
[Guo, Yongyong]'s Articles
[Hu, Chenyan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Lianguo]‘s Articles
[Guo, Yongyong]‘s Articles
[Hu, Chenyan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院水生生物研究所 - Feedback
Powered by CSpace