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题名: Composition and transcription of all interferon regulatory factors (IRFs), IRF1-11 in a perciform fish, the mandarin fish, Siniperca chuatsi
作者: Laghari, Zubair Ahmed1, 2; Li, Li1; Chen, Shan Nan1; Huo, Hui Jun1; Huang, Bei3; Zhou, Ying1; Nie, P.1, 4, 5
关键词: IRF ; Transcription ; Mandarin fish ; Siniperca chuatsi
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2018-04-01
DOI: 10.1016/j.dci.2017.11.015
卷: 81, 页:127-140
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Immunology ; Zoology
研究领域[WOS]: Fisheries ; Immunology ; Zoology
英文摘要: Interferon regulatory factors (IRFs) are a family of mediators in various biological processes including immune modulation of interferon (IFN) and proinflammatory cytokine expression. However, the data on the complete composition of IRFs is rather limited in teleost fish. In the present study, all IRF members, i.e. IRF1-11 with two IRF4, IRF4a and IRF4b have been characterised in an aquaculture species of fish, the mandarin fish, Siniperca chuatsi, in addition to the previous report of IRF1, IRF2, IRF3 and IRF7 from the fish. These IRFs are constitutively expressed in various organs/tissues of the fish, and their expression can be induced following the stimulation of polyinosinic:polycytidylic acid (poly(I:C)) and the infection of infectious spleen and kidney necrosis virus (ISKNV), a viral pathogen of mandarin fish in aquaculture. The ISKNV infection induced the significant increase in the expression of some IRF genes, i.e. IRF2, IRF4a, IRF7, IRF9, IRF10 at 24 or 36 h post-infection (hpi) in spleen and head-kidney, and the significant increase of some other IRF genes, e.g. IRF1, IRF3, IRF4b, IRF5, IRF6, IRF8 at later stage of infection from 72, or 96, or even 120 hpi, which may imply the inhibitory effect of ISKNV on fish immune response. It is considered that the present study provides the first detailed analysis on all IRF members in an aquaculture species of fish, and can be served as the base for further investigation on the role of IRFs in teleost fish. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: NECROSIS VIRUS ISKNV ; COD GADUS-MORHUA ; MOLECULAR CHARACTERIZATION ; EXPRESSION ANALYSIS ; PARALICHTHYS-OLIVACEUS ; JAPANESE FLOUNDER ; ONCORHYNCHUS-MYKISS ; INFECTIOUS SPLEEN ; RAINBOW-TROUT ; POSITIVE FEEDBACK
语种: 英语
项目资助者: National Natural Science Foundation of China(31230075) ; China Agriculture Research System(CARS-46) ; "Strengthening and Development of Sindh Agriculture University Tandojam" Phase-I Programme in Pakistan ; University of Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology in the Institute of Hydrobiology, Chinese Academy of Sciences
WOS记录号: WOS:000424726900013
ISSN号: 0145-305X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50666
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Key Lab Aquaculture Dis Control,Minist Agr, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
5.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
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