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题名: Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems
作者: Du, Kang1, 2; Zhong, Zaixuan1, 2; Fang, Chengchi1, 2; Dai, Wei1, 2; Shen, Yanjun1, 2; Gan, Xiaoni1; He, Shunping1
关键词: Interferon regulatory factor (IRF) ; Interferon (IFN) ; Adaptive immune system (AIS) ; Vertebrate immunity ; Whole-genome duplication (WGD)
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2018-04-01
DOI: 10.1016/j.dci.2017.12.016
卷: 81, 页:324-333
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Immunology ; Zoology
研究领域[WOS]: Fisheries ; Immunology ; Zoology
英文摘要: Interferon regulatory factors (IRFs) were first discovered as transcription factors that regulate the transcription of human interferon (IFN)-beta. Increasing evidence shows that they might be important players involved in Adaptive immune system (AIS) evolution. Although numbers of IRFs have been identified in chordates, the evolutionary history and functional diversity of this gene family during the early evolution of vertebrates have remained obscure. Using IRF HMM profile and HMMER searches, we identified 148 IRFs in 11 vertebrates and 4 protochordates. For them, we reconstructed the phylogenetic relationships, determined the synteny conservation, investigated the profile of natural selection, and analyzed the expression patterns in four "living fossil" vertebrates: lamprey, elephant shark, coelacanth and bichir. The results from phylogeny and synteny analysis imply that vertebrate IRFs evolved from three predecessors, instead of four as suggested in a previous study, as results from an ancient duplication followed by special expansions and lost during the vertebrate evolution. The profile of natural selection and expression reveals functional dynamics during the process. Together, they suggest that the 2nd whole-genome duplication (2WGD) provided raw materials for innovation in the IRF family, and that the birth of type-I IFN might be an important factor inducing the establishment of IRF-mediated immune networks. As a member involved in the AIS evolution, IRF provide insights into the process and mechanism involved in the complexity and novelties of vertebrate immune systems. (C) 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
关键词[WOS]: CODON-SUBSTITUTION MODELS ; AMINO-ACID SITES ; TRANSCRIPTION FACTORS ; ADAPTIVE IMMUNITY ; CRYSTAL-STRUCTURE ; GENE-EXPRESSION ; SEA LAMPREY ; IRF FAMILY ; PROTEIN ; IFN
语种: 英语
项目资助者: National Natural Science Foundation of China(31372190)
WOS记录号: WOS:000424726900033
ISSN号: 0145-305X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50656
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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