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Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems
Du, Kang1,2; Zhong, Zaixuan1,2; Fang, Chengchi1,2; Dai, Wei1,2; Shen, Yanjun1,2; Gan, Xiaoni1; He, Shunping1
2018-04-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume81Pages:324-333
AbstractInterferon regulatory factors (IRFs) were first discovered as transcription factors that regulate the transcription of human interferon (IFN)-beta. Increasing evidence shows that they might be important players involved in Adaptive immune system (AIS) evolution. Although numbers of IRFs have been identified in chordates, the evolutionary history and functional diversity of this gene family during the early evolution of vertebrates have remained obscure. Using IRF HMM profile and HMMER searches, we identified 148 IRFs in 11 vertebrates and 4 protochordates. For them, we reconstructed the phylogenetic relationships, determined the synteny conservation, investigated the profile of natural selection, and analyzed the expression patterns in four "living fossil" vertebrates: lamprey, elephant shark, coelacanth and bichir. The results from phylogeny and synteny analysis imply that vertebrate IRFs evolved from three predecessors, instead of four as suggested in a previous study, as results from an ancient duplication followed by special expansions and lost during the vertebrate evolution. The profile of natural selection and expression reveals functional dynamics during the process. Together, they suggest that the 2nd whole-genome duplication (2WGD) provided raw materials for innovation in the IRF family, and that the birth of type-I IFN might be an important factor inducing the establishment of IRF-mediated immune networks. As a member involved in the AIS evolution, IRF provide insights into the process and mechanism involved in the complexity and novelties of vertebrate immune systems. (C) 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
SubtypeArticle
KeywordInterferon Regulatory Factor (Irf) Interferon (Ifn) Adaptive Immune System (Ais) Vertebrate Immunity Whole-genome Duplication (Wgd)
DOI10.1016/j.dci.2017.12.016
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31372190) ; National Natural Science Foundation of China(31372190) ; National Natural Science Foundation of China(31372190) ; National Natural Science Foundation of China(31372190)
Language英语
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS KeywordCODON-SUBSTITUTION MODELS ; AMINO-ACID SITES ; TRANSCRIPTION FACTORS ; ADAPTIVE IMMUNITY ; CRYSTAL-STRUCTURE ; GENE-EXPRESSION ; SEA LAMPREY ; IRF FAMILY ; PROTEIN ; IFN
WOS IDWOS:000424726900033
Funding OrganizationNational Natural Science Foundation of China(31372190) ; National Natural Science Foundation of China(31372190) ; National Natural Science Foundation of China(31372190) ; National Natural Science Foundation of China(31372190)
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/50656
Collection水生生物多样性与资源保护研究中心
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Du, Kang,Zhong, Zaixuan,Fang, Chengchi,et al. Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,81:324-333.
APA Du, Kang.,Zhong, Zaixuan.,Fang, Chengchi.,Dai, Wei.,Shen, Yanjun.,...&He, Shunping.(2018).Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,81,324-333.
MLA Du, Kang,et al."Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 81(2018):324-333.
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