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题名: The dose makes the poison
作者: Chen, Liang1, 2; Giesy, John P.3, 4; Xie, Ping1, 5
关键词: Microcystin ; Low-dose ; Tumor ; Equivalent doses ; Inter-species variations ; Experimental design
刊名: SCIENCE OF THE TOTAL ENVIRONMENT
发表日期: 2018-04-15
DOI: 10.1016/j.scitotenv.2017.11.218
卷: 621, 页:649-653
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: Some microcystins (MCs) might cause hepatotoxicity in animals and humans. MC-LR is also a tumor promoter and a suspect carcinogen. In 2010, the International Agency for Research on Cancer (IARC) classified MC-LR as a possible human carcinogen (Group 2B). Recently, an article entitled "Long-term, low-dose exposure to microcystin toxin does not increase the risk of liver tumor development or growth in mice"was published in Hepatology Research by Meaghan Labine and Gerald Y. Minuk. However, the experimental design was flawed and the conclusion is misleading. 1 mu g/L MC-LR in drinking water is the provisional guideline value established by the World Health Organization (WHO) for humans in 1998, based on a tolerable daily intake (TDI) of 0.04 mu g/kg body mass (BM). Assuming the mice drink 1.5 mL/10 g BM of water per day, the exposure dose would be 0.15 mu g/kg/d BM, about 270-fold less than 40 mu g/kg/d, the no-observed-adverse-effect level (NOAEL). Thus, the dose of MC-LR was too small and "unlikely to result in liver tumor development or enhance existing tumor growth", even with a long-term (28 weeks) exposure. Presumably, they didn't consider inter-species variations between mice and humans, including toxicokinetics and toxicodynamics. Ranges of "low-dose"MCs for animals and humans should be defined. Also, the authorsmisunderstood or misrepresented several previous studies. Before drawing final conclusions on the carcinogenicity of MCs, further well-designed experiments are warranted. (C) 2017 Elsevier B.V. All rights reserved.
关键词[WOS]: MICROCYSTIN-LR ; CYANOBACTERIAL TOXINS ; POTENTIAL CARCINOGENICITY ; COMPARATIVE TOXICOLOGY ; TOXICITY ; GLUTATHIONE ; MOUSE ; RISK ; RAT ; IDENTIFICATION
语种: 英语
项目资助者: National Natural Science Foundations of China(31770555 ; State Key Laboratory of Freshwater Ecology and Biotechnology(2016FBZ08) ; "High Level Foreign Experts" program - State Administration of Foreign Experts Affairs, the P.R. China(GDT20143200016) ; Einstein Professor Program of the Chinese Academy of Sciences ; Canada Research Chair program ; Distinguished Visiting Professorship in the School of Biological Sciences of the University of Hong Kong ; 31600423)
WOS记录号: WOS:000424196800065
ISSN号: 0048-9697
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50650
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada
4.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
5.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810016, Peoples R China
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