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题名: PRIMARY-STRUCTURAL AND EVOLUTIONARY ANALYSES OF THE GROWTH-HORMONE GENE FROM GRASS CARP (CTENOPHARYNGODON-IDELLUS)
作者: ZHU, Z; HE, L; CHEN, TT
刊名: EUROPEAN JOURNAL OF BIOCHEMISTRY
发表日期: 1992-07-15
卷: 207, 期:2, 页:643-648
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The growth-hormone (GH) gene of grass carp, one of the fastest-growing species of farmed fish, was isolated and the DNA sequenced. Only one GH gene is found in this species. This gene, which is 2.5 kb in length, has five exons and four introns, in common with all of the mammalian and the recently published common-carp GH genes. In the course of vertebrate evolution, the total lengths of the intron and the non-coding region of exon 5 of the GH gene have been shortened by 40-70%, whereas the encoding exons of the gene have been slightly increased. The more closely related species exhibit the closest sequence similarity in their GH genes. For example, the similarity of the exons is 84.1 - 93.2% between grass carp and common carp (within the same family of Syprinedae), 43.5 -82.1% between grass carp and rainbow trout (in different orders of Teleostei) and 45.8-58.6% between grass carp and rat (in different grades of Vertebrata). In addition, similar DNA domains, such as thyroid-hormone-receptor-complex-binding site and cell-type-specific cis elements involved in regulation of expression of rat and human GH genes, have been localized in the corresponding regions of the grass-carp GH gene.
关键词[WOS]: COMPLETE NUCLEOTIDE-SEQUENCE ; MOLECULAR-CLONING ; ESCHERICHIA-COLI ; EXPRESSION ; CDNA ; ACTIVATION ; RECEPTOR ; PROMOTER ; DNA
语种: 英语
WOS记录号: WOS:A1992JF21200028
ISSN号: 0014-2956
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/50575
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.UNIV MARYLAND,CTR MARINE BIOTECHNOL,BALTIMORE,MD 21201
2.CHINESE ACAD SCI,INST HYDROBIOL,HUBEI,PEOPLES R CHINA
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