中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
题名: Claudin7b is required for the formation and function of inner ear in zebrafish
作者: Li, Xiaohui1, 2; Song, Guili1; Zhao, Yasong1, 2; Zhao, Feng3; Liu, Chunyan1; Liu, Dong3; Li, Qing1; Cui, Zongbin1
关键词: claudin7b ; hearing loss ; inner ear ; tight junction ; zebrafish
刊名: JOURNAL OF CELLULAR PHYSIOLOGY
发表日期: 2018-04-01
DOI: 10.1002/jcp.26162
卷: 233, 期:4, 页:3195-3206
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Cell Biology ; Physiology
研究领域[WOS]: Cell Biology ; Physiology
英文摘要: Zebrafish has become an excellent model for studying the development and function of inner ear. We report here a zebrafish line in which claudin 7b (cldn7b) locus is interrupted by a Tol2 transposon at its first intron. The homozygous mutants have enlarged otocysts, smaller or no otoliths, slowly formed semicircular canals, and insensitiveness to sound stimulation. These abnormal phenotypes and hearing loss of inner ear could be mostly rescued by injection of cldn7b-mRNA into one-cell stage homozygous mutant embryos. Mechanistically, cldn7b-deficiency interrupted the formation of apical junction complexes (AJCs) in otic epithelial cells of inner ear and the ion-homeostasis of endolymph, which then led to the loss of proper contact between otoliths and normally developed hair cells in utricle and saccule or aberrant mechanosensory transduction. Thus, Cldn7b is essential for the formation and proper function of inner ear through its unique role in keeping an initial integrity of otic epithelia during zebrafish embryogenesis.
关键词[WOS]: OTOLITH FORMATION ; CILIARY MOTILITY ; TIGHT JUNCTION ; VERTEBRATE EAR ; HAIR-CELLS ; EXPRESSION ; EMBRYOS ; MECHANISMS ; COMPLEX ; ABILITY
语种: 英语
项目资助者: National Natural Science Foundation of China(31571504 ; National Basic Research Program of China(2012CB944500) ; 31571496)
WOS记录号: WOS:000418723200050
ISSN号: 0021-9541
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/43673
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Xiaohui]'s Articles
[Song, Guili]'s Articles
[Zhao, Yasong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Xiaohui]‘s Articles
[Song, Guili]‘s Articles
[Zhao, Yasong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院水生生物研究所 - Feedback
Powered by CSpace