IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Polymorphisms in the Myostatin-l gene and their association with growth traits in Ancherythroculter nigrocauda
Sun Yanhong1; Li Qing1; Wang Guiying1; Zhu Dongmei1; Chen Jian1; Li Pei1; Tong Jingou2
2017
Source PublicationChinese Journal of Oceanology and Limnology
ISSN0254-4059
Volume35Issue:3Pages:597
AbstractMyostatin (MSTN) is a member of the transforming growth factor-β gene superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda, an economically important freshwater fish, were screened for single nucleotide polymorphisms (SNPs) and then genotyped by direct sequencing of PCR products. Five SNPs were identified in intron 1 and exon 2, including a non-synonymous mutation causing an amino acid change (Val to Ile) at position 180. Association analyses based on 300 individuals revealed that the g.1129T>C SNP locus was significantly associated with total length (TL),body length (BL),body height (BH) and body weight (BW) in 6- and 18-month-old populations, while the g.l289G>A locus was significantly associated with BH and BW in the 6-month-old population. Haplotype analyses revealed that fish with the genotype combinations TC/TC or TC/GA showed better growth performance. Our results suggest that g.1129T>C and g.1289G>A have positive effects on growth traits and may be candidate gene markers for marker-assisted selection in A. nigrocauda.
KeywordMyostatin-l (MSTN-1) single nucleotide polymorphisms (SNPs) Ancherythroculter nigrocauda growth traits association analysis
Language英语
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/42325
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Affiliation1.Wuhan Aquaculture Science Research Institute
2.中国科学院水生生物研究所
Recommended Citation
GB/T 7714
Sun Yanhong,Li Qing,Wang Guiying,et al. Polymorphisms in the Myostatin-l gene and their association with growth traits in Ancherythroculter nigrocauda[J]. Chinese Journal of Oceanology and Limnology,2017,35(3):597.
APA Sun Yanhong.,Li Qing.,Wang Guiying.,Zhu Dongmei.,Chen Jian.,...&Tong Jingou.(2017).Polymorphisms in the Myostatin-l gene and their association with growth traits in Ancherythroculter nigrocauda.Chinese Journal of Oceanology and Limnology,35(3),597.
MLA Sun Yanhong,et al."Polymorphisms in the Myostatin-l gene and their association with growth traits in Ancherythroculter nigrocauda".Chinese Journal of Oceanology and Limnology 35.3(2017):597.
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