| Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio) | |
Xu, Wenjie1; Li, Hongyan1,2; Wu, Liyun1,2; Dong, Bo1,2; Jin, Junyan1 ; Han, Dong1; Zhu, Xiaoming1; Yang, Yunxia1; Liu, Haokun1; Xie, Shouqi1
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| Corresponding Author | Jin, Junyan(jinjunyan@ihb.ac.cn) |
| 2020-11-19 | |
| Source Publication | FRONTIERS IN ENDOCRINOLOGY
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| ISSN | 1664-2392 |
| Volume | 11Pages:10 |
| Abstract | Normally, fish will decrease food intake or even stop feeding during the winter. In previous studies, two widely cultured gibel carp strains (strain A and strain F) showed differences in lipid and glucose metabolism. Therefore, we hypothesized that the physiological changes during the overwintering period would be different between the two strains. Thus, the two strains were starved for 77 days, after which the levels of glucose and lipid metabolism, ER stress, autophagy, and apoptosis were determined. The starvation increased hepatic glycogenolysis and fatty acid beta-oxidation but suppressed lipogenesis in both strains overwintering. Considering the effects of genotype, strain F had higher levels of ER stress and autophagy but lower levels of apoptosis than strain A, suggesting that strain F might be more resistant to overwintering starvation. The interactions between strains and starvation periods were observed in plasma triglyceride contents and the mRNA levels of pyruvate kinase (pk), sterol regulatory element binding protein 1 (srebp1), activating transcription factor 4 (atf4), and autophagy protein 12 (atg12). In conclusion, long-term starvation during winter could induce hepatic glycogenolysis and fatty acid beta-oxidation but suppress lipogenesis, ER stress, autophagy, and apoptosis in gibel carp, and strain F may be more resistant to starvation during winter. Taken together, these results discovered the responses to prolonged starvation stress during winter in two strains of gibel carp and could provide information for genotype selection, especially for selecting strains better adapted to winter. |
| Keyword | starvation cold stress strain endoplasmic reticulum stress autophagy apoptosis |
| DOI | 10.3389/fendo.2020.578777 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[U19A2041] ; National Natural Science Foundation of China[31972805] ; National Key R&D Program of China[2018YFD0900605] ; National Key R&D Program of China[2019YFD0900200] ; China Agriculture Research System[CARS-45-09] ; Science and Technology Service Network Initiative[Y82Z131201] |
| WOS Research Area | Endocrinology & Metabolism |
| WOS Subject | Endocrinology & Metabolism |
| WOS ID | WOS:000595119200001 |
| WOS Keyword | ENDOPLASMIC-RETICULUM STRESS ; RAINBOW-TROUT ; CELL-SURVIVAL ; AUTOPHAGY ; EXPRESSION ; APOPTOSIS ; DEATH ; GLUCOKINASE ; RESISTANCE ; PERK |
| Publisher | FRONTIERS MEDIA SA |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative ; Science and Technology Service Network Initiative |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/39374 |
| Collection | 藻类生物技术和生物能源研发中心_期刊论文 |
| Corresponding Author | Jin, Junyan |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Wenjie,Li, Hongyan,Wu, Liyun,et al. Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio)[J]. FRONTIERS IN ENDOCRINOLOGY,2020,11:10. |
| APA | Xu, Wenjie.,Li, Hongyan.,Wu, Liyun.,Dong, Bo.,Jin, Junyan.,...&Xie, Shouqi.(2020).Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio).FRONTIERS IN ENDOCRINOLOGY,11,10. |
| MLA | Xu, Wenjie,et al."Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio)".FRONTIERS IN ENDOCRINOLOGY 11(2020):10. |
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