| Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates | |
Zhang, Jing1,2,3,4; Chen, Kai2; Jiang, Chuanqi1,2,3,4; Yang, Wentao2; Gu, Siyu2,5; Wang, Guangying2; Lu, Yishan1,2; Miao, Wei2,6,7; Xiong, Jie2
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| Corresponding Author | Xiong, Jie(xiongjie@ihb.ac.cn) |
| 2020-11-01 | |
| Source Publication | MICROORGANISMS
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| Volume | 8Issue:11Pages:13 |
| Abstract | Scuticociliatosis is an invasive external or systemic infection caused by ciliated protozoa, mainly those within the subclass Scuticociliatia (scuticociliates). Many scuticociliates are fish pathogens, including Miamiensis avidus, Philasterides dicentrarchi, Pseudocohnilembus persalinus, and Uronema marinum. Our previous study showed that hemolysis-related genes derived from bacteria through horizontal gene transfer (HGT) may contribute to virulence in P. persalinus. Hemorrhagic lesions are a common feature of scuticociliatosis, but it is not known whether other scuticociliates also have bacteria-derived hemolysis-related genes. In this study, we constructed a high-quality macronuclear genome of another typical pathogenic scuticociliate, U. marinum. A total of 105 HGT genes were identified in this species, of which 35 were homologs of hemolysis-related genes (including hemolysin-like genes) that had previously been identified in P. persalinus. Sequencing of an additional five species from four scuticociliate families showed that bacteria-derived hemolysis-related genes (especially hemolysin-like genes) are widely distributed in scuticociliates. Based on these findings, we suggest that hemolysin-like genes may have originated before the divergence of scuticociliates. |
| Keyword | scuticociliatosis Uronema marinum MAC genome hemolysis-III like protein |
| DOI | 10.3390/microorganisms8111838 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31525021] ; National Natural Science Foundation of China[91631303] ; National Natural Science Foundation of China[31672281] ; National Natural Science Foundation of China[31872221] ; Natural Science Foundation of Hubei Province[2019CFB808] ; Shenzhen Science and Technology Project[JCYJ20180507183240459] ; China Postdoctoral Science Foundation[2019M652735] ; China Postdoctoral Science Foundation[2020M682528] |
| WOS Research Area | Microbiology |
| WOS Subject | Microbiology |
| WOS ID | WOS:000593170100001 |
| WOS Keyword | PHILASTERIDES-DICENTRARCHI CILIOPHORA ; GENOME ; HISTOPATHOLOGY ; EXPRESSION ; INFECTION ; ALIGNMENT ; TAXONOMY ; SEQUENCE ; INSIGHTS ; PROTOZOA |
| Publisher | MDPI |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Hubei Province ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; Shenzhen Science and Technology Project ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/39355 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Xiong, Jie |
| Affiliation | 1.Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 3.Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China 4.Shenzhen Dapeng New Dist Sci & Technol Innovat Se, Shenzhen 518119, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China 7.CAS Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Jing,Chen, Kai,Jiang, Chuanqi,et al. Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates[J]. MICROORGANISMS,2020,8(11):13. |
| APA | Zhang, Jing.,Chen, Kai.,Jiang, Chuanqi.,Yang, Wentao.,Gu, Siyu.,...&Xiong, Jie.(2020).Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates.MICROORGANISMS,8(11),13. |
| MLA | Zhang, Jing,et al."Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates".MICROORGANISMS 8.11(2020):13. |
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