IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus
Xiao, Fanshu1; Liao, Lanjie2; Xu, Qiaoqing3; He, Zhili1,4; Xiao, Tiaoyi4; Wang, Jianjun5; Huang, Jie2; Yu, Yuhe2; Wu, Bo1; Yan, Qingyun1
Corresponding AuthorYan, Qingyun(yanqy6@mail.sysu.edu.cn)
2020-11-25
Source PublicationENVIRONMENTAL MICROBIOLOGY
ISSN1462-2912
Pages17
AbstractGut microbiota could facilitate host to defense diseases, but fish-microbiota interactions during viral infection and the underlying mechanism are poorly understood. We examined interactions and responses of gut microbiota to grass carp reovirus (GCRV) infection in Ctenopharyngodon idellus, which is the most important aquaculture fish worldwide. We found that GCRV infection group with serious haemorrhagic symptoms (G7s) showed considerably different gut microbiota, especially with an abnormally high abundance of gram-negative anaerobic Cetobacterium somerae. It also showed the lowest (p < 0.05) alpha-diversity but with much higher ecological process of homogenizing dispersal (28.8%), confirming a dysbiosis of the gut microbiota after viral infection. Interestingly, signaling pathways of NOD-like receptors (NLRs), toll-like receptors (TLRs), and lipopolysaccharide (LPS) stimulation genes were significantly (q-value < 0.01) enriched in G7s, which also significantly (p < 0.01) correlated with the core gut microbial genera of Cetobacterium and Acinetobacter. The results suggested that an expansion of C. somerae initiated by GCRV could aggravate host inflammatory reactions through the LPS-related NLRs and TLRs pathways. This study advances our understanding of the interplay between fish immunity and gut microbiota challenged by viruses; it also sheds new insights for ecological defense of fish diseases with the help of gut microbiota.
DOI10.1111/1462-2920.15330
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31802350] ; National Natural Science Foundation of China[92051120] ; National Natural Science Foundation of China[31672262] ; National Natural Science Foundation of China[31800417] ; Foundation of the State Key Laboratory of Applied Microbiology Southern China[SKLAM005-2018] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2019333] ; Fundamental Research Funds for the Central Universities[19lgzd28] ; Fundamental Research Funds for the Central Universities[19lgpy164] ; Hundred Talents Program through Sun Yat-sen University[18821107]
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
WOS IDWOS:000592122400001
WOS KeywordGUT MICROBIOTA ; INNATE IMMUNITY ; BACTERIAL COMMUNITIES ; CETOBACTERIUM-SOMERAE ; FISH ; HEALTH ; DIVERSITY ; EVOLUTION ; INSIGHTS ; DISEASE
PublisherWILEY
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/39334
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorYan, Qingyun
Affiliation1.Sun Yat Sen Univ, Sch Environm Sci & Engn, Environm Microbi Res Ctr, Southern Marine Sci & Engn Guangdong Lab Zhuhai, Guangzhou 510006, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
3.Yangtze Univ, Sch Anim Sci, Jingzhou 434020, Peoples R China
4.Hunan Agr Univ, Coll Agron, Coll Anim Sci & Technol, Changsha 410128, Peoples R China
5.Nanjing Inst Geog & Limnol, Chinese Acad Sci, State Key Lab Lake Sci & Environm, Nanjing 210008, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Fanshu,Liao, Lanjie,Xu, Qiaoqing,et al. Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus[J]. ENVIRONMENTAL MICROBIOLOGY,2020:17.
APA Xiao, Fanshu.,Liao, Lanjie.,Xu, Qiaoqing.,He, Zhili.,Xiao, Tiaoyi.,...&Yan, Qingyun.(2020).Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus.ENVIRONMENTAL MICROBIOLOGY,17.
MLA Xiao, Fanshu,et al."Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus".ENVIRONMENTAL MICROBIOLOGY (2020):17.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiao, Fanshu]'s Articles
[Liao, Lanjie]'s Articles
[Xu, Qiaoqing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiao, Fanshu]'s Articles
[Liao, Lanjie]'s Articles
[Xu, Qiaoqing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiao, Fanshu]'s Articles
[Liao, Lanjie]'s Articles
[Xu, Qiaoqing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.