| Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus | |
| Xiao, Fanshu1; Liao, Lanjie2; Xu, Qiaoqing3; He, Zhili1,4; Xiao, Tiaoyi4; Wang, Jianjun5; Huang, Jie2; Yu, Yuhe2; Wu, Bo1; Yan, Qingyun1 | |
| Corresponding Author | Yan, Qingyun(yanqy6@mail.sysu.edu.cn) |
| 2020-11-25 | |
| Source Publication | ENVIRONMENTAL MICROBIOLOGY
 |
| ISSN | 1462-2912 |
| Pages | 17 |
| Abstract | Gut microbiota could facilitate host to defense diseases, but fish-microbiota interactions during viral infection and the underlying mechanism are poorly understood. We examined interactions and responses of gut microbiota to grass carp reovirus (GCRV) infection in Ctenopharyngodon idellus, which is the most important aquaculture fish worldwide. We found that GCRV infection group with serious haemorrhagic symptoms (G7s) showed considerably different gut microbiota, especially with an abnormally high abundance of gram-negative anaerobic Cetobacterium somerae. It also showed the lowest (p < 0.05) alpha-diversity but with much higher ecological process of homogenizing dispersal (28.8%), confirming a dysbiosis of the gut microbiota after viral infection. Interestingly, signaling pathways of NOD-like receptors (NLRs), toll-like receptors (TLRs), and lipopolysaccharide (LPS) stimulation genes were significantly (q-value < 0.01) enriched in G7s, which also significantly (p < 0.01) correlated with the core gut microbial genera of Cetobacterium and Acinetobacter. The results suggested that an expansion of C. somerae initiated by GCRV could aggravate host inflammatory reactions through the LPS-related NLRs and TLRs pathways. This study advances our understanding of the interplay between fish immunity and gut microbiota challenged by viruses; it also sheds new insights for ecological defense of fish diseases with the help of gut microbiota. |
| DOI | 10.1111/1462-2920.15330 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31802350] ; National Natural Science Foundation of China[92051120] ; National Natural Science Foundation of China[31672262] ; National Natural Science Foundation of China[31800417] ; Foundation of the State Key Laboratory of Applied Microbiology Southern China[SKLAM005-2018] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2019333] ; Fundamental Research Funds for the Central Universities[19lgzd28] ; Fundamental Research Funds for the Central Universities[19lgpy164] ; Hundred Talents Program through Sun Yat-sen University[18821107] |
| WOS Research Area | Microbiology |
| WOS Subject | Microbiology |
| WOS ID | WOS:000592122400001 |
| WOS Keyword | GUT MICROBIOTA ; INNATE IMMUNITY ; BACTERIAL COMMUNITIES ; CETOBACTERIUM-SOMERAE ; FISH ; HEALTH ; DIVERSITY ; EVOLUTION ; INSIGHTS ; DISEASE |
| Publisher | WILEY |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Foundation of the State Key Laboratory of Applied Microbiology Southern China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University ; Hundred Talents Program through Sun Yat-sen University |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/39334 |
| Collection | 水生生物多样性与资源保护研究中心_期刊论文 |
| Corresponding Author | Yan, Qingyun |
| Affiliation | 1.Sun Yat Sen Univ, Sch Environm Sci & Engn, Environm Microbi Res Ctr, Southern Marine Sci & Engn Guangdong Lab Zhuhai, Guangzhou 510006, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 3.Yangtze Univ, Sch Anim Sci, Jingzhou 434020, Peoples R China 4.Hunan Agr Univ, Coll Agron, Coll Anim Sci & Technol, Changsha 410128, Peoples R China 5.Nanjing Inst Geog & Limnol, Chinese Acad Sci, State Key Lab Lake Sci & Environm, Nanjing 210008, Peoples R China |
| Recommended Citation GB/T 7714 | Xiao, Fanshu,Liao, Lanjie,Xu, Qiaoqing,et al. Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus[J]. ENVIRONMENTAL MICROBIOLOGY,2020:17. |
| APA | Xiao, Fanshu.,Liao, Lanjie.,Xu, Qiaoqing.,He, Zhili.,Xiao, Tiaoyi.,...&Yan, Qingyun.(2020).Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus.ENVIRONMENTAL MICROBIOLOGY,17. |
| MLA | Xiao, Fanshu,et al."Host-microbiota interactions and responses to grass carp reovirus infection in Ctenopharyngodon idellus".ENVIRONMENTAL MICROBIOLOGY (2020):17. |
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