IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction
Lu, Long-Feng1,2; Li, Zhuo-Cong1,2; Zhang, Can1,2; Zhou, Xiao-Yu1,3; Zhou, Yu1,2; Jiang, Jing-Yu1,2; Chen, Dan-Dan1,2; Li, Shun1,2; Zhang, Yong-An1,4
Corresponding AuthorLi, Shun(bob@ihb.ac.cn) ; Zhang, Yong-An(yonganzhang@mail.hzau.edu.cn)
2020-10-26
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume11Pages:15
AbstractViruses typically target host RIG-I-like receptors (RLRs), a group of key factors involved in interferon (IFN) production, to enhance viral infection. To date, though immune evasion methods to contradict IFN production have been characterized for a series of terrestrial viruses, the strategies employed by fish viruses remain unclear. Here, we report that all grass carp reovirus (GCRV) proteins encoded by segments S1 to S11 suppress mitochondrial antiviral signaling protein (MAVS)-mediated IFN expression. First, the GCRV viral proteins blunted the MAVS-induced expression of IFN, and impair MAVS antiviral capacity significantly. Interestingly, subsequent co-immunoprecipitation experiments demonstrated that all GCRV viral proteins interacted with several RLR cascades, especially with TANK-binding kinase 1 (TBK1) which was the downstream factor of MAVS. To further illustrate the mechanisms of these interactions between GCRV viral proteins and host RLRs, two of the viral proteins, NS79 (S4) and VP3 (S3), were selected as representative proteins for two distinguished mechanisms. The obtained data demonstrated that NS79 was phosphorylated by gcTBK1, leading to the reduction of host substrate gcIRF3/7 phosphorylation. On the other hand, VP3 degraded gcMAVS and the degradation was significantly reversed by 3-MA. The biological effects of both NS79 and VP3 were consistently found to be related to the suppression of IFN expression and the promotion of viral evasion. Our findings shed light on the special evasion mechanism utilized by fish virus through IFN regulation, which might differ between fish and mammals.
KeywordGCRV viral proteins immune evasion MAVS interferon
DOI10.3389/fimmu.2020.545302
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFD0900504] ; National Natural Science Foundation of China[31725026] ; National Natural Science Foundation of China[31802338] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011] ; Youth Innovation Promotion Association
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000587376100001
WOS KeywordNF-KAPPA-B ; INNATE IMMUNE-RESPONSE ; ADAPTER PROTEIN ; GENE-EXPRESSION ; INTERFERON ; VIRUS ; TBK1 ; IDENTIFICATION ; INDUCTION ; PHOSPHORYLATION
PublisherFRONTIERS MEDIA SA
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/39293
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorLi, Shun; Zhang, Yong-An
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing, Peoples R China
3.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian, Peoples R China
4.Huazhong Agr Univ, Coll Fisheries, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Lu, Long-Feng,Li, Zhuo-Cong,Zhang, Can,et al. Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction[J]. FRONTIERS IN IMMUNOLOGY,2020,11:15.
APA Lu, Long-Feng.,Li, Zhuo-Cong.,Zhang, Can.,Zhou, Xiao-Yu.,Zhou, Yu.,...&Zhang, Yong-An.(2020).Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction.FRONTIERS IN IMMUNOLOGY,11,15.
MLA Lu, Long-Feng,et al."Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS Signaling Transduction".FRONTIERS IN IMMUNOLOGY 11(2020):15.
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