IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi
Li, Li1,2; Chen, Shan Nan1,2; Nie, P.1,2,3,4
Corresponding AuthorNie, P.(pinnie@ihb.ac.cn)
2021
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume114Pages:7
AbstractIn vertebrates, a total of eleven interferon (IFN) regulatory factors (IRFs), IRF1 to IRF11 are reported, with the conserved presence of IRF1 to IRF9 in all classes of vertebrates. However, IRF10 has been reported only in fish and birds, and IRF11 seems to be a fish specific IRF member. In this study, IRF11 in mandarin fish Siniperca chuatsi was found upregulated following virus infection, and IRF11 was localized constitutively in nucleus as revealed through immunofluorescence test. The overexpression and/or luciferase reporter assays showed that IRF11 can induce transcriptionally the ISRE activity, and the expression of type I IFNs, IFNc and IFNh, as well as the IFN-stimulated gene, Mx, thus inhibiting the Siniperca chuatsi rhabdovirus (SCRV) replication as indicated in the reduced expression of virus protein genes. It is thus suggested that IRF11 in mandarin fish and probably in other teleost fish can exert its antiviral effect through the upregulation of type I IFNs and ISGs.
KeywordIRF11 IFN Type I IFN ISRE Transcription Rhabdovirus Siniperca chuatsi Mandarin fish
DOI10.1016/j.dci.2020.103846
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFD0900501] ; China Agriculture Research System[CARS-46] ; special top talent plan One Thing One Decision programme in Shandong Province, China[(2018)27] ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China[(2018)8]
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS IDWOS:000588061100040
WOS KeywordCONSTITUTIVE EXPRESSION ; ZEBRAFISH IRF1 ; PERCIFORM FISH ; INTERFERON ; REVEALS ; FAMILY ; GENES ; ACTIVATION ; INDUCTION ; IFN-PHI-1
PublisherELSEVIER SCI LTD
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/39250
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, P.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquaculture Dis Control, Wuhan 430072, Hubei, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
4.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Li, Li,Chen, Shan Nan,Nie, P.. IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,114:7.
APA Li, Li,Chen, Shan Nan,&Nie, P..(2021).IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,114,7.
MLA Li, Li,et al."IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 114(2021):7.
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