| IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi | |
| Li, Li1,2; Chen, Shan Nan1,2; Nie, P.1,2,3,4 | |
| Corresponding Author | Nie, P.(pinnie@ihb.ac.cn) |
| 2021 | |
| Source Publication | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| ISSN | 0145-305X |
| Volume | 114Pages:7 |
| Abstract | In vertebrates, a total of eleven interferon (IFN) regulatory factors (IRFs), IRF1 to IRF11 are reported, with the conserved presence of IRF1 to IRF9 in all classes of vertebrates. However, IRF10 has been reported only in fish and birds, and IRF11 seems to be a fish specific IRF member. In this study, IRF11 in mandarin fish Siniperca chuatsi was found upregulated following virus infection, and IRF11 was localized constitutively in nucleus as revealed through immunofluorescence test. The overexpression and/or luciferase reporter assays showed that IRF11 can induce transcriptionally the ISRE activity, and the expression of type I IFNs, IFNc and IFNh, as well as the IFN-stimulated gene, Mx, thus inhibiting the Siniperca chuatsi rhabdovirus (SCRV) replication as indicated in the reduced expression of virus protein genes. It is thus suggested that IRF11 in mandarin fish and probably in other teleost fish can exert its antiviral effect through the upregulation of type I IFNs and ISGs. |
| Keyword | IRF11 IFN Type I IFN ISRE Transcription Rhabdovirus Siniperca chuatsi Mandarin fish |
| DOI | 10.1016/j.dci.2020.103846 |
| Funding Organization | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFD0900501] ; China Agriculture Research System[CARS-46] ; special top talent plan One Thing One Decision programme in Shandong Province, China[(2018)27] ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China[(2018)8] |
| WOS Research Area | Fisheries ; Immunology ; Zoology |
| WOS Subject | Fisheries ; Immunology ; Zoology |
| WOS ID | WOS:000588061100040 |
| WOS Keyword | CONSTITUTIVE EXPRESSION ; ZEBRAFISH IRF1 ; PERCIFORM FISH ; INTERFERON ; REVEALS ; FAMILY ; GENES ; ACTIVATION ; INDUCTION ; IFN-PHI-1 |
| Publisher | ELSEVIER SCI LTD |
| Funding Organization | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan One Thing One Decision programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China ; special top talent plan First Class Fishery Discipline programme in Shandong Province, China |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/39250 |
| Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
| Corresponding Author | Nie, P. |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquaculture Dis Control, Wuhan 430072, Hubei, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 4.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Li,Chen, Shan Nan,Nie, P.. IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,114:7. |
| APA | Li, Li,Chen, Shan Nan,&Nie, P..(2021).IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,114,7. |
| MLA | Li, Li,et al."IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 114(2021):7. |
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