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Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae
Fu, Juanjuan1,2; Guo, Yongyong1; Wang, Min1; Yang, Lihua1; Han, Jian1; Lee, Jae-Seong3; Zhou, Bingsheng1
Corresponding AuthorHan, Jian(hanjian@ihb.ac.cn)
2020-12-15
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume206Pages:9
Abstract2,4,6-tribromophenol (TBP) is generally used as a brominated flame retardant but is produced in the degradation of tetrabromobisphenol-A. Although TBP is frequently detected in the environment and in various biota, including fish species, we still know little about its toxicity and environmental health risk. Here we investigated the bioconcentration and effects of TBP on the thyroid endocrine system by using zebrafish as a model. Zebrafish embryos (2 h post-fertilization, hpf) were exposed to five concentrations of TBP (0, 0.3, 1, 10, and 100 mu g/L) until 144 hpf. According to our chemical analysis, TBP underwent bioconcentration in zebrafish larvae. However, acute exposure to TBP did not affect the hatching of embryos or their risk of malformation, nor the growth and survival of larvae, indicating low developmental toxicity of TBP. The whole-body thyroxine (T4) contents were significantly increased in zebrafish larvae after exposure to TBP, indicating thyroid endocrine disruption occurred. Gene transcription levels in the hypothalamic-pituitary-thyroid (HPT) axis were also examined in larvae; these results revealed that the transcription of corticotrophin-releasing hormone (crh), thyrotropin-releasing hormone (trh), and thyroid-stimulating hormone (tsh beta) were all significantly downregulated by exposure to TBP. Likewise, genes encoding thyronine deiodinases (dio1, dio2, and dio3a/b) and thyroid hormone receptors (tr alpha and tr beta) also had their transcription downregulated in zebrafish. Further, the gene transcription and protein expression of binding and transport protein transthyretin (TTR) were significantly increased after TBP exposure. Taken together, our results suggest the bioavailability of and potential thyroid endocrine disruption by TBP in fish.
Keyword2,4,6-tribromophenol Thyroid endocrine disruption Hypothalamic-pituitary-thyroid axis Thyroid hormones Brominated flame retardant Zebrafish larvae
DOI10.1016/j.ecoenv.2020.111207
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFD0900701] ; National Natural Science Foundation of China[21737005] ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances[PTS2019-04]
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS IDWOS:000582222400040
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; DECABROMODIPHENYL ETHANE ; HORMONE RECEPTORS ; MESSENGER-RNAS ; HUMAN EXPOSURE ; BROMOPHENOLS ; EXPRESSION ; GROWTH ; PBDES
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances ; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/39222
Collection水环境工程研究中心_期刊论文
Corresponding AuthorHan, Jian
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea
Recommended Citation
GB/T 7714
Fu, Juanjuan,Guo, Yongyong,Wang, Min,et al. Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,206:9.
APA Fu, Juanjuan.,Guo, Yongyong.,Wang, Min.,Yang, Lihua.,Han, Jian.,...&Zhou, Bingsheng.(2020).Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,206,9.
MLA Fu, Juanjuan,et al."Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 206(2020):9.
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