IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
Specific cyprinid HIF isoforms contribute to cellular mitochondrial regulation
Chen, Jing1,4; Guan, Lihong2; Zou, Ming1,4; He, Shunping3; Li, Dapeng1,4; Chi, Wei1,4
Corresponding AuthorChi, Wei(bluetorry@163.com)
2020-10-14
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume10Issue:1Pages:13
AbstractHypoxia-inducible factor 1 (HIF-1) functions as a master regulator of the cellular response to hypoxic stress. Two HIF-1 alpha paralogs, HIF-1 alpha A and HIF-1 alpha B, were generated in euteleosts by the specific, third round of genome duplication, but one paralog was later lost in most families with the exception of cyprinid fish. How these duplicates function in mitochondrial regulation and whether their preservation contributes to the hypoxia tolerance demonstrated by cyprinid fish in freshwater environments is not clear. Here we demonstrated the divergent function of these two zebrafish Hif-1a paralogs through cellular approaches. The results showed that Hif-1aa played a role in tricarboxylic acid cycle by increasing the expression of Citrate synthase and the activity of mitochondrial complex II, and it also enhanced mitochondrial membrane potential and ROS production by reducing free Ca2+ in the cytosol. Hif-1ab promoted intracellular ATP content by up-regulating the activity of mitochondrial complexes I, III and IV and the expression of related genes. Furthermore, both the two zebrafish Hif-1a paralogs promoted mitochondrial mass and the expression level of mtDNA, contributing to mitochondrial biogenesis. Our study reveals the divergent functions of Hif-1aa and Hif-1ab in cellular mitochondrial regulation.
DOI10.1038/s41598-020-74210-w
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31401977] ; earmarked fund for China Agriculture Research System[CARS-45] ; Fundamental Research Funds for the Central Universities[2662015PY119]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000582678700040
WOS KeywordWHOLE-GENOME DUPLICATION ; OXIDATIVE-PHOSPHORYLATION ; ELECTRON-TRANSPORT ; DYSFUNCTION ; BIOGENESIS ; EVOLUTION ; CA2+ ; ROS ; INHIBITION ; METABOLISM
PublisherNATURE RESEARCH
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; earmarked fund for China Agriculture Research System ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/39219
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorChi, Wei
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Natl Demonstrat Ctr Expt Aquaculture Educ, Wuhan 430070, Peoples R China
2.Xinxiang Med Univ, Coll Life Sci & Technol, Xinxiang, Henan, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
4.Hubei Prov Engn Lab Pond Aquaculture, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jing,Guan, Lihong,Zou, Ming,et al. Specific cyprinid HIF isoforms contribute to cellular mitochondrial regulation[J]. SCIENTIFIC REPORTS,2020,10(1):13.
APA Chen, Jing,Guan, Lihong,Zou, Ming,He, Shunping,Li, Dapeng,&Chi, Wei.(2020).Specific cyprinid HIF isoforms contribute to cellular mitochondrial regulation.SCIENTIFIC REPORTS,10(1),13.
MLA Chen, Jing,et al."Specific cyprinid HIF isoforms contribute to cellular mitochondrial regulation".SCIENTIFIC REPORTS 10.1(2020):13.
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