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Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation
Zhang, Ting1,3; Guan, PengPeng2; Liu, WenYe1; Zhao, Guang1; Fang, YaPing2; Fu, Hui5; Gui, Jian-Fang4; Li, GuoLiang2; Liu, Jing-Xia1
Corresponding AuthorLi, GuoLiang(guoliang.li@mail.hzau.edu.cn) ; Liu, Jing-Xia(ichliu@mail.hzau.edu.cn)
2020-10-01
Source PublicationBIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
ISSN1874-9399
Volume1863Issue:10Pages:16
AbstractUnbalanced copper (Cu) homeostasis is associated with neurological development defects and diseases. However, the molecular mechanisms remain elusive. Here, central neural system (CNS) myelin defects and the down-regulated expression of WNT/NOTCH signaling and its down-stream mediator hoxb5b were observed in Cu2+ stressed zebrafish larvae. The loss/knockdown-of-function of hoxb5b phenocopied the myelin and axon defects observed in Cu2+ stressed embryos. Meanwhile, the activation of WNT/NOTCH signaling and ectopic expression of hoxb5b could rescue Cu induced myelin defects. Additionally, fam168b, similar to pou3f1/2, exhibited significant promoter hypermethylation and reduced expression in Cu2+ stressed embryos. The hypermethylated locus in fam168b promoter acted pivotally in its transcription, and the loss/knockdown of fam168b/pou3f1 also induced myelin defects. This study also demonstrated that fam168b/pou3f1 and hoxb5b axis acted in a seesaw manner during fish embryogenesis: Cu induced the down-regulated expression of the WNT &NOTCH-hoxb5b axis through the function of copper transporter cox17, coupled with the promoter methylation of genes fam168b/pou3f1, and its subsequent down-regulated expression through the function of another transporter atp7b, making joint contributions to myelin defects in embryos.
KeywordCopper Myelin hoxb5b fam168b/pou3f1 DNA methylation
DOI10.1016/j.bbagrm.2020.194612
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFD0900101] ; Fundamental Research Funds for the Central University[2662018JC024] ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China[31771402]
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000574417000002
WOS KeywordWHITE-MATTER ; MOTOR-NEURON ; WNT ; EXPRESSION ; OLIGODENDROCYTES ; DIFFERENTIATION ; ABNORMALITIES ; DEFICIENCY ; METABOLISM ; ACTIVATION
PublisherELSEVIER
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of key laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38947
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorLi, GuoLiang; Liu, Jing-Xia
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Anim Breeding, Minist Agr, Wuhan 430070, Peoples R China
2.Huazhong Agr Univ, Coll Informat, Hubei Engn Technol Res Ctr Agr Big Data, Agr Bioinformat Key Lab Hubei Prov, Wuhan 430070, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, Guangzhou 510301, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
5.Wuhan Univ, Sch Basic Med Sci, Dept Anat, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ting,Guan, PengPeng,Liu, WenYe,et al. Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2020,1863(10):16.
APA Zhang, Ting.,Guan, PengPeng.,Liu, WenYe.,Zhao, Guang.,Fang, YaPing.,...&Liu, Jing-Xia.(2020).Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1863(10),16.
MLA Zhang, Ting,et al."Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1863.10(2020):16.
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