IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity
Xu, Hao-Yue1,2; Dong, Fen1; Zhai, Xue1; Meng, Kai-Feng1; Han, Guang-Kun1; Cheng, Gao-Feng1; Wu, Zheng-Ben1; Li, Nan3; Xu, Zhen1,2
Corresponding AuthorXu, Zhen(zhenxu@mail.hzau.edu.cn)
2020-09-23
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume11Pages:14
AbstractThe buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial pathogens, however, very little is known about the evolutionary roles of buccal MALT in immune defense. Here we developed a bath infection model that rainbow trout experimentally exposed toFlavobacterium columnare(F. columnare), which is well known as a mucosal pathogen. Using this model, we provided the first evidence for the process of bacterial invasion in the fish BM. Moreover, strong pathogen-specific IgT responses and accumulation of IgT(+)B-cells were induced in the buccal mucus and BM of infected trout withF. columnare. In contrast, specific IgM responses were for the most part detected in the fish serum. More specifically, we showed that the local proliferation of IgT(+)B-cells and production of pathogen-specific IgT within the BM upon bacterial infection. Overall, our findings represent the first demonstration that IgT is the main Ig isotype specialized for buccal immune responses against bacterial infection in a non-tetrapod species.
Keywordevolution mucosal immunoglobulins B-cells buccal mucosa bacterial infection
DOI10.3389/fimmu.2020.562795
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFD0900400] ; National Natural Science Foundation of China[31873045]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000575619500001
WOS KeywordRAINBOW-TROUT ; COLUMNARIS DISEASE ; ORAL-CAVITY ; B-CELLS ; IGA ; ZEBRAFISH ; FLAVOBACTERIUM ; INFECTION ; ISOTYPE ; PATHWAY
PublisherFRONTIERS MEDIA SA
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38928
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorXu, Zhen
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Dept Aquat Anim Med, Wuhan, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Xu, Hao-Yue,Dong, Fen,Zhai, Xue,et al. Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity[J]. FRONTIERS IN IMMUNOLOGY,2020,11:14.
APA Xu, Hao-Yue.,Dong, Fen.,Zhai, Xue.,Meng, Kai-Feng.,Han, Guang-Kun.,...&Xu, Zhen.(2020).Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity.FRONTIERS IN IMMUNOLOGY,11,14.
MLA Xu, Hao-Yue,et al."Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity".FRONTIERS IN IMMUNOLOGY 11(2020):14.
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