| Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction | |
| Lu, Long-Feng1,2; Zhang, Can1,3; Zhou, Xiao-Yu1,4; Li, Zhuo-Cong1,3; Chen, Dan-Dan1,2; Zhou, Yu1,3; Zhou, Fang1; Zhang, Yong-An5; Li, Shun1,2 | |
| Corresponding Author | Li, Shun(bob@ihb.ac.cn) |
| 2020-10-01 | |
| Source Publication | JOURNAL OF IMMUNOLOGY
 |
| ISSN | 0022-1767 |
| Volume | 205Issue:7Pages:1819-+ |
| Abstract | IFN is essential for hosts to defend against viral invasion, whereas it must be tightly regulated to prevent hyperimmune responses. Fish mitochondrial antiviral signaling protein (MAVS) is a vital factor for IFN production, but until now, there have been few studies on the regulation mechanisms of fish MAVS enabling IFN to be properly controlled. In this study, we show that zebrafish RNAbinding motif protein 47 (RBM47) promotesMAVS degradation in a lysosome-dependent manner to suppress IFN production. First, the transcription of IFN activated by polyinosinic/polycytidylic acid (poly I:C), spring viremia of carp virus, or retinoic acid-inducible gene I (RIG-I)-like receptor pathway components were significantly suppressed by RBM47. Second, RBM47 interacted with MAVS and promoted lysosome-dependent degradation of MAVS, changing the cellular location of MAVS from the cytoplasm to the lysosome region. Finally, RBM47 inhibited downstream MITA and IRF3/7 activation, impairing the host antiviral response. Collectively, these data suggest that zebrafish RBM47 negatively regulates IFN production by promoting lysosome-dependent degradation of MAVS, providing insights into the role of RBM47 in the innate antiviral immune response in fish. |
| DOI | 10.4049/jimmunol.1901387 |
| Funding Organization | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFD0900504] ; Youth Innovation Promotion Association ; National Natural Science Foundation of China[31802338] |
| WOS Research Area | Immunology |
| WOS Subject | Immunology |
| WOS ID | WOS:000574415200010 |
| WOS Keyword | PATTERN-RECOGNITION RECEPTORS ; ANTIVIRAL SIGNALING PROTEIN ; RNA-BINDING PROTEIN ; RIG-I ; ADAPTER PROTEIN ; TARGETING MAVS ; INTERFERON ; ACTIVATION ; IRF3 ; GENE |
| Publisher | AMER ASSOC IMMUNOLOGISTS |
| Funding Organization | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/38919 |
| Collection | 分析测试中心_期刊论文 |
| Corresponding Author | Li, Shun |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430070, Peoples R China 5.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, Long-Feng,Zhang, Can,Zhou, Xiao-Yu,et al. Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction[J]. JOURNAL OF IMMUNOLOGY,2020,205(7):1819-+. |
| APA | Lu, Long-Feng.,Zhang, Can.,Zhou, Xiao-Yu.,Li, Zhuo-Cong.,Chen, Dan-Dan.,...&Li, Shun.(2020).Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction.JOURNAL OF IMMUNOLOGY,205(7),1819-+. |
| MLA | Lu, Long-Feng,et al."Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction".JOURNAL OF IMMUNOLOGY 205.7(2020):1819-+. |
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