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Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)
Gan, Zhen1,2,3,4,5,6; Cheng, Jun1,3,4,5; Chen, Shannan2; Laghari, Zubair Ahmed2; Hou, Jing1,2,3,4,5,6; Xia, Liqun1,3,4,5; Lu, Yishan1,3,4,5; Nie, Pin2,7
Corresponding AuthorLu, Yishan(fishdis@163.com) ; Nie, Pin(pinnie@ihb.ac.cn)
2020-10-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume105Pages:86-94
AbstractInterferons are a family of class II alpha-helical cytokines playing vital roles in antiviral immune response, and little information is available to date regarding the interferon system of tilapia. In this study, a type I IFN gene, named On-IFNc, was identified in Nile tilapia, Oreochromis niloticus. The predicted protein of On-IFNc contains several structural features known in type I IFNs, and On-IFNc was clustered together with the known IFNc in fish into a separated Glade in the phylogenetic tree. On-IFNc gene was constitutively expressed in all tissues examined, with the highest expression level observed in liver, and was rapidly induced in all organs/tissues tested following the stimulation of poly(I:C). In addition, recombinant On-IFNc has been proven to markedly induce the expression of the antiviral effectors, Mx and viperin, the signalling components, STAT1, STAT2, and IRF9, and the transcription factors, IRF3 and IRF7, as well as the tyrosine phosphorylation of STAT1 and STAT2 in fish cells. Furthermore, recombinant On-IFNc has been proven to possess antiviral activity against ISKNV. The present study thus contributes to a better understanding of the functional properties of the type I IFN system in tilapia.
KeywordOreochromis niloticus Type I interferon Interferon-stimulated genes Tyrosine phosphorylation Antiviral activity
DOI10.1016/j.fsi.2020.06.036
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[31320103913] ; China Agriculture Research System[CARS-46] ; special talent programme One Thing One Decision
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000571888900004
WOS KeywordKIDNEY NECROSIS VIRUS ; ATLANTIC SALMON ; MOLECULAR CHARACTERIZATION ; INFECTIOUS SPLEEN ; IMMUNE-RESPONSE ; RAINBOW-TROUT ; EXPRESSION ; GENES ; IDENTIFICATION ; DISTINCT
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38894
Collection其他_期刊论文
Corresponding AuthorLu, Yishan; Nie, Pin
Affiliation1.Guangdong Ocean Univ, Shenzhen Inst, 3 Binhai 2nd Rd, Shenzhen 518120, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524025, Peoples R China
4.Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China
5.Shenzhen Publ Serv Platform Evaluat Marine Econ A, Shenzhen 518120, Peoples R China
6.Shenzhen Dapeng New Dist Sci & Technol Innovat Se, Shenzhen 518120, Peoples R China
7.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Gan, Zhen,Cheng, Jun,Chen, Shannan,et al. Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)[J]. FISH & SHELLFISH IMMUNOLOGY,2020,105:86-94.
APA Gan, Zhen.,Cheng, Jun.,Chen, Shannan.,Laghari, Zubair Ahmed.,Hou, Jing.,...&Nie, Pin.(2020).Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus).FISH & SHELLFISH IMMUNOLOGY,105,86-94.
MLA Gan, Zhen,et al."Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)".FISH & SHELLFISH IMMUNOLOGY 105(2020):86-94.
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