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题名: Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia
作者: Da Fonte, Dillon F.1; Martyniuk, Christopher J.2, 3; Xing, Lei1, 5; Pelin, Adrian1; Corradi, Nicolas1; Hu, Wei4; Trudeau, Vance L.1
刊名: SCIENTIFIC REPORTS
发表日期: 2017-11-02
DOI: 10.1038/s41598-017-14930-8
卷: 7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Radial glial cells (RGCs) are the most abundant macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis; however, their transcriptome remains uncharacterized, which limits functional understanding of this important cell type. Using cultured goldfish RGCs, RNA sequencing and de novo transcriptome assembly were performed, generating the first reference transcriptome for fish RGCs with 17,620 unique genes identified. These data revealed that RGCs express a diverse repertoire of receptors and signaling molecules, suggesting that RGCs may respond to and synthesize an array of hormones, peptides, cytokines, and growth factors. Building upon neuroanatomical data and studies investigating direct neuronal regulation of RGC physiology, differential gene expression analysis was conducted to identify transcriptional networks that are responsive to the conserved secretogranin II-derived neuropeptide secretoneurin A (SNa). Pathway analysis of the transcriptome indicated that cellular processes related to the central nervous system (e.g., neurogenesis, synaptic plasticity, glial cell development) and immune functions (e.g., immune system activation, leukocyte function, macrophage response) were preferentially modulated by SNa. These data reveal an array of new functions that are proposed to be critical to neuronal-glial interactions through the mediator SNa.
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; II CHROMOGRANIN-C ; ADULT ZEBRAFISH ; TELEOST FISH ; NEURAL PROGENITORS ; NEUROPEPTIDE SECRETONEURIN ; NEURONAL REGENERATION ; ALZHEIMERS-DISEASE ; ESTROGEN-RECEPTORS ; CELL-MIGRATION
语种: 英语
项目资助者: NSERC ; CGSM ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship
WOS记录号: WOS:000414261500047
ISSN号: 2045-2322
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/38883
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada
2.Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32611 USA
3.Univ Florida, Coll Vet Med, Interdisciplinary Program Biomed Sci Neurosci, Genet Inst,Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
5.Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
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