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The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120
Wang, Zi-Qian1,2,3; Wang, Suqin1,2,3; Zhang, Ju-Yuan1,2; Lin, Gui-Ming1,2; Gan, Nanqin1,2; Song, Lirong1,2; Zeng, Xiaoli1,2; Zhang, Cheng-Cai1,2,4,5,6
Corresponding AuthorZeng, Xiaoli(zengxl@ihb.ac.cn) ; Zhang, Cheng-Cai(cczhang@ihb.ac.cn)
2020-08-01
Source PublicationTOXINS
Volume12Issue:8Pages:14
AbstractProduced by cyanobacteria and some plants, BMAA is considered as an important environmental factor in the occurrence of some neurodegenerative diseases. Neither the underlying mechanism of its toxicity, nor its biosynthetic or metabolic pathway in cyanobacteria is understood. Interestingly, BMAA is found to be toxic to some cyanobacteria, making it possible to dissect the mechanism of BMAA metabolism by genetic approaches using these organisms. In this study, we used the cyanobacteriumAnabaenaPCC 7120 to isolate BMAA-resistant mutants. Following genomic sequencing, several mutations were mapped to two genes involved in amino acids transport, suggesting that BMAA was taken up through amino acid transporters. This conclusion was supported by the protective effect of several amino acids against BMAA toxicity. Furthermore, targeted inactivation of genes encoding different amino acid transport pathways conferred various levels of resistance to BMAA. One mutant inactivating all three major amino acid transport systems could no longer take up BMAA and gained full resistance to BMAA toxicity. Therefore, BMAA is a substrate of amino acid transporters, and cyanobacteria are interesting models for genetic analysis of BMAA transport and metabolism.
Keywordneurodegenerative disease cyanobacteria amino acids transport BMAA resistance
DOI10.3390/toxins12080518
Funding OrganizationKey Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences
Indexed BySCI ; SCI
Language英语
Funding ProjectKey Research Program of Frontier Sciences of the Chinese Academy of Sciences[QYZDJ-SSW-SMC016] ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences[Y85Z061601] ; Chinese Academy of Sciences[Y65Z021501]
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000564125300001
WOS Keyword2,4-DIAMINOBUTYRIC ACID ; CYANOBACTERIAL NEUROTOXINS ; FRESH-WATER ; DAB ; GROWTH ; SEEDS
PublisherMDPI
Funding OrganizationKey Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38718
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorZeng, Xiaoli; Zhang, Cheng-Cai
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Aix Marseille Univ, Inst AMU WUT, Wuhan 430072, Peoples R China
5.Wuhan Univ Technol, Wuhan 430072, Peoples R China
6.Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zi-Qian,Wang, Suqin,Zhang, Ju-Yuan,et al. The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120[J]. TOXINS,2020,12(8):14.
APA Wang, Zi-Qian.,Wang, Suqin.,Zhang, Ju-Yuan.,Lin, Gui-Ming.,Gan, Nanqin.,...&Zhang, Cheng-Cai.(2020).The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120.TOXINS,12(8),14.
MLA Wang, Zi-Qian,et al."The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120".TOXINS 12.8(2020):14.
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