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Transport of Ciliary Membrane Proteins
Long, Huan1,2,3; Huang, Kaiyao1
Corresponding AuthorHuang, Kaiyao(huangky@ihb.ac.cn)
2020-01-13
Source PublicationFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN2296-634X
Volume7Pages:9
AbstractCilia and flagella are highly conserved organelles in eukaryotic cells that drive cell movement and act as cell antennae that receive and transmit signals. In addition to receiving and transducing external signals that activate signal cascades, cilia also secrete ciliary ectosomes that send signals to recipient cells, and thereby mediate cell-cell communication. Abnormal ciliary function leads to various ciliopathies, and the precise transport and localization of ciliary membrane proteins are essential for cilium function. This review summarizes current knowledge about the transport processes of ciliary membrane proteins after their synthesis at the endoplasmic reticulum: modification and sorting in the Golgi apparatus, transport through vesicles to the ciliary base, entrance into cilia through the diffusion barrier, and turnover by ectosome secretion. The molecular mechanisms and regulation involved in each step are also discussed. Transport of ciliary membrane proteins is a complex, precise cellular process coordinated among multiple organelles. By systematically analyzing the existing research, we identify topics that should be further investigated to promote progress in this field of research.
Keywordcilia ciliary membrane protein diffusion barrier ciliary ectosome ciliopathies
DOI10.3389/fcell.2019.00381
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31671399] ; National Natural Science Foundation of China[31401154] ; Chinese Government Scholarship
WOS Research AreaCell Biology ; Developmental Biology
WOS SubjectCell Biology ; Developmental Biology
WOS IDWOS:000559266600001
WOS KeywordPRIMARY CILIUM ; EXTRACELLULAR VESICLES ; PROTEOMIC ANALYSIS ; TRANSITION ZONE ; CHLAMYDOMONAS-REINHARDTII ; COUPLED RECEPTORS ; GOLGI-COMPLEX ; TRAFFICKING ; RAB8 ; MECHANISMS
PublisherFRONTIERS MEDIA SA
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38691
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorHuang, Kaiyao
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan, Peoples R China
2.Univ Calif Berkeley, Dept Plant Biol, Berkeley, CA 94720 USA
3.Univ Calif Berkeley, Dept Microbial Biol, Berkeley, CA 94720 USA
Recommended Citation
GB/T 7714
Long, Huan,Huang, Kaiyao. Transport of Ciliary Membrane Proteins[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,7:9.
APA Long, Huan,&Huang, Kaiyao.(2020).Transport of Ciliary Membrane Proteins.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,7,9.
MLA Long, Huan,et al."Transport of Ciliary Membrane Proteins".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 7(2020):9.
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