IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis
Shi, Lixia1,2; Wang, Nenghan1,2; Hu, Xudong1,2; Yin, Dacong3; Wu, Chenxi1; Liang, Huifang4; Cao, Wenxuan1; Cao, Hong1
Corresponding AuthorCao, Hong(regancao@ihb.ac.cn)
2020-08-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume78Pages:11
AbstractLead (Pb) is a toxic heavy metal that can cause significant damage to the aquatic ecosystem. In this study, acute toxicity test of lead in rare minnow (Gobiocypris rarus) was conducted. The average LC50 for 96 h of Pb2+ is 423.01 mu g/L (95 % CI: 338.41-531.92 mu g/L). The order of bioaccumulation of Pb2+ was gills>kidney>intestine>liver>muscle>brain. A number of cellular and tissue alterations were observed in the gill, liver, kidney and intestine tissues of Pb2+-treated rare minnows through the histological examination performed by H&E and TEM analyses. Furthermore, we investigated the Pb2+-induced toxicity mechanisms in rare minnow based on transcriptome analyses, and a panel of immune-related genes were identified and evaluated by real-time quantitative PCR. In summary, our work indicates that rare minnow could be a valuable model for studying the mechanisms of lead acute toxicity in fish.
KeywordRare minnow Pb(2+)acute toxicity Histopathology Mitochondria
DOI10.1016/j.etap.2020.103385
Funding OrganizationCRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program
Indexed BySCI ; SCI
Language英语
Funding ProjectCRSRI Open Research Program[SN: CKWV2017533/KY]
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000549174200004
WOS KeywordPEARL RIVER ESTUARY ; HEAVY-METAL ; IMMUNE-RESPONSES ; RAINBOW-TROUT ; LIVER ; FISH ; WATER ; GILL ; MODEL ; BIOACCUMULATION
PublisherELSEVIER
Funding OrganizationCRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38549
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorCao, Hong
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Changjiang River Sci Res Inst, Wuhan 430010, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Peoples R China
Recommended Citation
GB/T 7714
Shi, Lixia,Wang, Nenghan,Hu, Xudong,et al. Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2020,78:11.
APA Shi, Lixia.,Wang, Nenghan.,Hu, Xudong.,Yin, Dacong.,Wu, Chenxi.,...&Cao, Hong.(2020).Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,78,11.
MLA Shi, Lixia,et al."Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 78(2020):11.
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