| Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis | |
Shi, Lixia1,2; Wang, Nenghan1,2; Hu, Xudong1,2; Yin, Dacong3; Wu, Chenxi1; Liang, Huifang4; Cao, Wenxuan1; Cao, Hong1
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| Corresponding Author | Cao, Hong(regancao@ihb.ac.cn) |
| 2020-08-01 | |
| Source Publication | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| ISSN | 1382-6689 |
| Volume | 78Pages:11 |
| Abstract | Lead (Pb) is a toxic heavy metal that can cause significant damage to the aquatic ecosystem. In this study, acute toxicity test of lead in rare minnow (Gobiocypris rarus) was conducted. The average LC50 for 96 h of Pb2+ is 423.01 mu g/L (95 % CI: 338.41-531.92 mu g/L). The order of bioaccumulation of Pb2+ was gills>kidney>intestine>liver>muscle>brain. A number of cellular and tissue alterations were observed in the gill, liver, kidney and intestine tissues of Pb2+-treated rare minnows through the histological examination performed by H&E and TEM analyses. Furthermore, we investigated the Pb2+-induced toxicity mechanisms in rare minnow based on transcriptome analyses, and a panel of immune-related genes were identified and evaluated by real-time quantitative PCR. In summary, our work indicates that rare minnow could be a valuable model for studying the mechanisms of lead acute toxicity in fish. |
| Keyword | Rare minnow Pb(2+)acute toxicity Histopathology Mitochondria |
| DOI | 10.1016/j.etap.2020.103385 |
| Funding Organization | CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | CRSRI Open Research Program[SN: CKWV2017533/KY] |
| WOS Research Area | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| WOS Subject | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| WOS ID | WOS:000549174200004 |
| WOS Keyword | PEARL RIVER ESTUARY ; HEAVY-METAL ; IMMUNE-RESPONSES ; RAINBOW-TROUT ; LIVER ; FISH ; WATER ; GILL ; MODEL ; BIOACCUMULATION |
| Publisher | ELSEVIER |
| Funding Organization | CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/38549 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Cao, Hong |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Changjiang River Sci Res Inst, Wuhan 430010, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Peoples R China |
| Recommended Citation GB/T 7714 | Shi, Lixia,Wang, Nenghan,Hu, Xudong,et al. Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2020,78:11. |
| APA | Shi, Lixia.,Wang, Nenghan.,Hu, Xudong.,Yin, Dacong.,Wu, Chenxi.,...&Cao, Hong.(2020).Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,78,11. |
| MLA | Shi, Lixia,et al."Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 78(2020):11. |
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