| Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary | |
Song, Yanlong1; Chen, Ji1; Tao, Binbin1; Luo, Daji1; Zhu, Zuoyan1; Hu, Wei1,2
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| Corresponding Author | Hu, Wei(huwei@ihb.ac.cn) |
| 2020-08-01 | |
| Source Publication | MOLECULAR AND CELLULAR ENDOCRINOLOGY
 |
| ISSN | 0303-7207 |
| Volume | 513Pages:8 |
| Abstract | Kisspeptin2 is a neuropeptide widely found in the brain and multiple peripheral tissues in the zebrafish. The pituitary is the center of synthesis and secretes various endocrine hormones. However, Kiss2 innervation in the zebrafish pituitary is unknown. In this study, the organization of Kiss2 cells and structures in the zebrafish pituitary by promoter-driving mCherry-labeling Kiss2 neurons were investigated. Kiss2 neurons in the hypothalamus do not project into the pituitary. Kiss2 cells are found in the female pituitary. Unidentified Kiss2 cells and extensions are located in the proximal pars distalis (PPD), similar to the distribution of Gnrh3 fibers. Kiss2 structures reside alongside Gnrh3 fibers. No Kiss2 structures are found in the male pituitary. The transcriptional expression of the kisspeptin receptor kiss1rb is detected in both female and male pituitaries. In situ hybridization shows that kiss1rb-positive cells are located in the PPD and pars intermedia (PI). In vitro Kiss2-10 treatment stimulates Akt and Erk phosphorylation and significantly induces lh beta, fsh beta, and prl1 mRNA expression in the female pituitary. The results in this study suggest that Kiss2 and Kiss1rb may form an independent paracrine or autocrine system in the female zebrafish pituitary. Kiss2 and Kiss1rb signaling regulates the expression of pituitary hormones. |
| Keyword | Kiss2 kiss1rb Gnrh3 Hormone Pituitary Zebrafish |
| DOI | 10.1016/j.mce.2020.110858 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31672661] ; National Natural Science Foundation of China[31802289] ; Chinese Academy of Sciences[152342KYSB20180019] ; Chinese Academy of Sciences[2019FBZ05] |
| WOS Research Area | Cell Biology ; Endocrinology & Metabolism |
| WOS Subject | Cell Biology ; Endocrinology & Metabolism |
| WOS ID | WOS:000548713200004 |
| WOS Keyword | NEURONS ; GENE ; ACTIVATION ; RECEPTORS ; SECRETION ; PATTERNS ; CLONING ; SYSTEM |
| Publisher | ELSEVIER IRELAND LTD |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/38533 |
| Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
| Corresponding Author | Hu, Wei |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Innovat Acad Seed Design, Wuhan 430072, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Qingdao 266237, Peoples R China |
| Recommended Citation GB/T 7714 | Song, Yanlong,Chen, Ji,Tao, Binbin,et al. Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2020,513:8. |
| APA | Song, Yanlong,Chen, Ji,Tao, Binbin,Luo, Daji,Zhu, Zuoyan,&Hu, Wei.(2020).Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary.MOLECULAR AND CELLULAR ENDOCRINOLOGY,513,8. |
| MLA | Song, Yanlong,et al."Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary".MOLECULAR AND CELLULAR ENDOCRINOLOGY 513(2020):8. |
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