IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Zebrafishprmt3negatively regulates antiviral responses
Zhu, Junji1,2; Liu, Xing1,3,4; Cai, Xiaolian1,2; Ouyang, Gang1,3,4; Zha, Huangyuan1,5; Zhou, Ziwen1,2; Liao, Qian1,2; Wang, Jing1,3,4; Xiao, Wuhan1,2,3,4,6
Corresponding AuthorXiao, Wuhan(w-xiao@ihb.ac.cn)
2020-07-08
Source PublicationFASEB JOURNAL
ISSN0892-6638
Pages16
AbstractArginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in histone and nonhistone proteins, which regulates many cellular functions. Protein arginine methyltransferase 3 (prmt3), a type I arginine methyltransferase, has been shown to carry out the formation of stable monomethylarginine as an intermediate before the establishment of asymmetric dimethylarginine. To date, however, the role of PRMT3 in antiviral innate immunity has not been elucidated. This study showed that zebrafishprmt3was upregulated by virus infection and that the overexpression ofprmt3suppressed cellular antiviral response. The PRMT3 inhibitor, SGC707, enhanced antiviral capability. Consistently,prmt3-null zebrafish were more resistant to Spring Viremia of Carp Virus (SVCV) and Grass Carp Reovirus (GCRV) infection. Further assays showed that the overexpression ofprmt3diminished the phosphorylation of irf3 and prmt3 interacted with rig-i. In addition, both zinc-finger domain and catalytic domain of prmt3 were required for the suppressive function ofprmt3on IFN activation. Our findings suggested that zebrafishprmt3negatively regulated the antiviral responses, implicating the vital role ofprmt3-or even arginine methylation-in antiviral innate immunity.
KeywordGCRV innate immunity prmt3 SVCV zebrafish
DOI10.1096/fj.201902569R
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
Indexed BySCI ; SCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDA 24010308] ; National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31671315] ; National Key R&D Program of China[2018YFD0900602]
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biology ; Cell Biology
WOS IDWOS:000547819100001
WOS KeywordARGININE N-METHYLTRANSFERASE ; INDUCIBLE GENE-I ; RIG-I ; SUBSTRATE-SPECIFICITY ; SPRING VIREMIA ; PRMT3 ; RECOGNITION ; METHYLATION ; RNA ; OLIGOMERIZATION
PublisherWILEY
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38461
Collection水环境工程研究中心_期刊论文
Corresponding AuthorXiao, Wuhan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Peoples R China
4.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
5.Dalian Ocean Univ, Dalian, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, Key Aquat Biodivers & Conservat, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Junji,Liu, Xing,Cai, Xiaolian,et al. Zebrafishprmt3negatively regulates antiviral responses[J]. FASEB JOURNAL,2020:16.
APA Zhu, Junji.,Liu, Xing.,Cai, Xiaolian.,Ouyang, Gang.,Zha, Huangyuan.,...&Xiao, Wuhan.(2020).Zebrafishprmt3negatively regulates antiviral responses.FASEB JOURNAL,16.
MLA Zhu, Junji,et al."Zebrafishprmt3negatively regulates antiviral responses".FASEB JOURNAL (2020):16.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu, Junji]'s Articles
[Liu, Xing]'s Articles
[Cai, Xiaolian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu, Junji]'s Articles
[Liu, Xing]'s Articles
[Cai, Xiaolian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu, Junji]'s Articles
[Liu, Xing]'s Articles
[Cai, Xiaolian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.