| ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling | |
| Sun, Xiaoyun1; Peng, Xixia1,2; Cao, Yuqin1,2; Zhou, Yan3; Sun, Yuhua1,2,4 | |
| Corresponding Author | Sun, Yuhua(sunyh@ihb.ac.cn) |
| 2020-06-12 | |
| Source Publication | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| Volume | 11Issue:1Pages:16 |
| Abstract | ADNP (Activity Dependent Neuroprotective Protein) is a neuroprotective protein whose aberrant expression has been frequently linked to neural developmental disorders, including the Helsmoortel-Van der Aa syndrome (also called the ADNP syndrome). However, its role in neural development and pathology remains unclear. Here, we show that ADNP is required for neural induction and differentiation by enhancing Wnt signaling. Mechanistically, ADNP functions to stabilize beta -Catenin through binding to its armadillo domain which prevents its association with key components of the degradation complex: Axin and APC. Loss of ADNP promotes the formation of the degradation complex and beta -Catenin degradation via ubiquitin-proteasome pathway, resulting in down-regulation of key neuroectoderm developmental genes. In addition, adnp gene disruption in zebrafish leads to defective neurogenesis and reduced Wnt signaling. Our work provides important insights into the role of ADNP in neural development and the pathology of the Helsmoortel-Van der Aa syndrome caused by ADNP gene mutation. ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via beta -Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling. |
| DOI | 10.1038/s41467-020-16799-0 |
| Funding Organization | National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program[2016YFA0101100] ; National Natural Science Foundation of China[31671526] ; Hundred-Talent Program (CAS)[Y623041501] ; Hundred-Talent Program (IHB)[Y623041501] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000542758700014 |
| WOS Keyword | DEPENDENT NEUROPROTECTIVE PROTEIN ; BETA-CATENIN ; SELF-RENEWAL ; STEM-CELLS ; PLURIPOTENCY ; CHROMATIN ; MUTATIONS ; INTERACTS ; BRAIN ; NAP |
| Publisher | NATURE PUBLISHING GROUP |
| Funding Organization | National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/38385 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Sun, Yuhua |
| Affiliation | 1.Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Med Res Inst, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Xiaoyun,Peng, Xixia,Cao, Yuqin,et al. ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling[J]. NATURE COMMUNICATIONS,2020,11(1):16. |
| APA | Sun, Xiaoyun,Peng, Xixia,Cao, Yuqin,Zhou, Yan,&Sun, Yuhua.(2020).ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling.NATURE COMMUNICATIONS,11(1),16. |
| MLA | Sun, Xiaoyun,et al."ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling".NATURE COMMUNICATIONS 11.1(2020):16. |
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