IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling
Sun, Xiaoyun1; Peng, Xixia1,2; Cao, Yuqin1,2; Zhou, Yan3; Sun, Yuhua1,2,4
Corresponding AuthorSun, Yuhua(sunyh@ihb.ac.cn)
2020-06-12
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume11Issue:1Pages:16
AbstractADNP (Activity Dependent Neuroprotective Protein) is a neuroprotective protein whose aberrant expression has been frequently linked to neural developmental disorders, including the Helsmoortel-Van der Aa syndrome (also called the ADNP syndrome). However, its role in neural development and pathology remains unclear. Here, we show that ADNP is required for neural induction and differentiation by enhancing Wnt signaling. Mechanistically, ADNP functions to stabilize beta -Catenin through binding to its armadillo domain which prevents its association with key components of the degradation complex: Axin and APC. Loss of ADNP promotes the formation of the degradation complex and beta -Catenin degradation via ubiquitin-proteasome pathway, resulting in down-regulation of key neuroectoderm developmental genes. In addition, adnp gene disruption in zebrafish leads to defective neurogenesis and reduced Wnt signaling. Our work provides important insights into the role of ADNP in neural development and the pathology of the Helsmoortel-Van der Aa syndrome caused by ADNP gene mutation. ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via beta -Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.
DOI10.1038/s41467-020-16799-0
Funding OrganizationNational Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB)
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program[2016YFA0101100] ; National Natural Science Foundation of China[31671526] ; Hundred-Talent Program (CAS)[Y623041501] ; Hundred-Talent Program (IHB)[Y623041501]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000542758700014
WOS KeywordDEPENDENT NEUROPROTECTIVE PROTEIN ; BETA-CATENIN ; SELF-RENEWAL ; STEM-CELLS ; PLURIPOTENCY ; CHROMATIN ; MUTATIONS ; INTERACTS ; BRAIN ; NAP
PublisherNATURE PUBLISHING GROUP
Funding OrganizationNational Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB)
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/38385
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorSun, Yuhua
Affiliation1.Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Med Res Inst, Wuhan 430071, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Sun, Xiaoyun,Peng, Xixia,Cao, Yuqin,et al. ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling[J]. NATURE COMMUNICATIONS,2020,11(1):16.
APA Sun, Xiaoyun,Peng, Xixia,Cao, Yuqin,Zhou, Yan,&Sun, Yuhua.(2020).ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling.NATURE COMMUNICATIONS,11(1),16.
MLA Sun, Xiaoyun,et al."ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling".NATURE COMMUNICATIONS 11.1(2020):16.
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