IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4
Sun, XiaoYun1; Yu, WenJun3; Li, Li2; Sun, YuHua1,3
Corresponding AuthorLi, Li(li.li@mail.hzau.edu.cn) ; Sun, YuHua(sunyh@ihb.ac.cn)
2020-07-01
Source PublicationFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN2296-634X
Volume8Pages:16
AbstractADNP (Activity Dependent Neuroprotective Protein) is proposed as a neuroprotective protein whose aberrant expression has been frequently linked to rare neural developmental disorders and cancers, including the recently described neurodevelopmental Helsmoortel-Van der Aa syndrome. Recent studies have suggested that ADNP functions as an important chromatin regulator. However, how ADNP-regulated chromatin mechanisms control gene expression and stem cell fate commitment remains unclear. Here we show that ADNP interacts with two chromatin remodelers, BRG1 and CHD4. ADNP is required for proper establishment of chromatin accessibility, nucleosome configuration, and bivalent histone modifications of developmental genes. Loss of ADNP leads to enhancer over-activation and increased ratio of H3K4me3/H3K27me3 at key primitive endoderm (PrE) gene promoters, resulting in prominent up-regulation of these genes and priming ES cell differentiation toward endodermal cell types. Thus, our work revealed a key role of ADNP in the establishment of local chromatin landscape and structure of developmental genes by association with BRG1 and CHD4. These findings provide further insights into the role of ADNP in the pathology of the Helsmoortel-Van der Aa syndrome.
KeywordADNP embryonic stem cells chromatin lineage-specifying genes BRG1 CHD4
DOI10.3389/fcell.2020.00553
Funding OrganizationNational Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Key Research and Development Program[2016YFA0101100] ; National Natural Science Foundation of China[31671526] ; CAS[Y623041501] ; NSFC[31771430] ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB[Y623041501]
WOS Research AreaCell Biology ; Developmental Biology
WOS SubjectCell Biology ; Developmental Biology
WOS IDWOS:000553060900001
WOS KeywordDEPENDENT NEUROPROTECTIVE PROTEIN ; NUCLEOSOME OCCUPANCY ; SELF-RENEWAL ; COMPLEX ; PLURIPOTENCY ; DIFFERENTIATION ; SITES ; BRAIN ; CELLS
PublisherFRONTIERS MEDIA SA
Funding OrganizationNational Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36877
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorLi, Li; Sun, YuHua
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China
2.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan, Peoples R China
3.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Sun, XiaoYun,Yu, WenJun,Li, Li,et al. ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,8:16.
APA Sun, XiaoYun,Yu, WenJun,Li, Li,&Sun, YuHua.(2020).ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8,16.
MLA Sun, XiaoYun,et al."ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8(2020):16.
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