IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Visual system: An understudied target of aquatic toxicology
Chen, Lianguo
Corresponding AuthorChen, Lianguo(lchenam@ihb.ac.cn)
2020-08-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume225Pages:12
AbstractVisual system is increasingly recognized as a sensitive target of xenobiotics in aquatic ecosystems. Various environmental pollutants of distinct physicochemical properties are able to impair the retinal development and function of teleost fishes, including dioxin-like pollutants, flame retardants, pesticides, perfluoroalkyl acids, retinoic acids and metals. Considering the availability of developmental and functional database, zebrafish has been the most frequently used as the teleost model to study aquatic visual toxicology. A diversity of visual deficits has been displayed for fishes across multiple levels of biological organizations (e.g., molecule, cell, histology, physiology and behavior). Covering sensitive developmental windows of eyes during early embryogenesis, acute or chronic exposure to xenobiotics can disturb the expressions of visual gene and protein markers, which affect the retinal neurogenesis and induce degeneration of neurons. Morphological structures and physiological responses of retina and optic rectum are then disorganized, eventually compromising the performance of visually-mediated behaviors and recruitment of individuals. Environmental pollutants can cross the blood-retina barrier and accumulate in eyes, which might impact visual system directly. In addition, pollutants are very likely to interrupt retinal development and function indirectly by disturbing the signaling of retinoids and thyroid. However, exact mechanisms of visual toxicity are largely unknown currently. In this review, the development and structure of retina and available tools for studying visual science are described briefly. Advances in visual toxicology are summarized in detail and outlooks for future visual toxicity studies are discussed.
KeywordVisual system Aquatic toxicology Visual toxicity Toxic mechanism Thyroid Retinoids
DOI10.1016/j.aquatox.2020.105542
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31971236] ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03]
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000551630500011
WOS KeywordDECABROMODIPHENYL ETHER BDE-209 ; POLYBROMINATED DIPHENYL ETHERS ; LONG-TERM EXPOSURE ; EARLY-LIFE STAGES ; PIKE ESOX-LUCIUS ; ZEBRAFISH LARVAE ; DEVELOPMENTAL TOXICITY ; EMBRYONIC EXPOSURE ; SUBLETHAL EXPOSURE ; DIETARY EXPOSURE
PublisherELSEVIER
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36871
Collection水环境工程研究中心_期刊论文
Corresponding AuthorChen, Lianguo
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lianguo. Visual system: An understudied target of aquatic toxicology[J]. AQUATIC TOXICOLOGY,2020,225:12.
APA Chen, Lianguo.(2020).Visual system: An understudied target of aquatic toxicology.AQUATIC TOXICOLOGY,225,12.
MLA Chen, Lianguo."Visual system: An understudied target of aquatic toxicology".AQUATIC TOXICOLOGY 225(2020):12.
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