IHB OpenIR
Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea)
Yan, Saihong1,2; Wang, Qi1,2,3; Yang, Lihua4; Zha, Jinmiao1,2,3
Corresponding AuthorZha, Jinmiao(jmzha@rcees.ac.cn)
2020-06-02
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume54Issue:11Pages:6850-6858
AbstractTo compare the toxicities of a chlorinated and a nonchlorinated organophosphorus flame retardant (OPFR) in this study, adult calms (Corbicula fluminea) were exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tributyl phosphate (TNBP) at 20, 200, and 2000 mu g/L for 30 days. Toxicity screening using transcriptomics indicated that the apoptosis pathway was significantly affected in the groups exposed to 2000 mu g/L TDCIPP and TNBP (p <= 0.05), and this finding was further confirmed by the protein interaction network. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay suggested that TDCIPP and TNBP can cause apoptosis. The significant (p <= 0.05) increases in the activities of caspases 3 and 8 obtained with all treatments and in that of caspase 9 obtained with 2000 mu g/L exposure treatments indicated the presence of mitochondria-dependent and mitochondria-independent apoptosis. Interestingly, a noticeable dose-dependent increase in DNA damage was observed in all treatments, resulting in apoptosis. Therefore, our results demonstrate that TDCIPP and TNBP induce DNA damage and apoptosis in C. fluminea, which indicates that these chemicals pose an ecological risk to benthic organisms. Moreover, through a similar mechanism of action in apoptosis, TDCIPP induced more serious toxicity than TNBP, which indicated that chlorination or differences in structure-specific metabolism could be key factors influencing toxicity.
DOI10.1021/acs.est.0c00640
Funding OrganizationMajor International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
Indexed BySCI ; SCI
Language英语
Funding ProjectMajor International Joint Research Project of the National Natural Science Foundation of China[51420105012] ; National Natural Science Foundation of China[21677165] ; China Postdoctoral Science Foundation[2018M641496]
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS IDWOS:000538420500042
WOS KeywordORGANOPHOSPHORUS FLAME RETARDANTS ; OXIDATIVE STRESS ; DNA-DAMAGE ; SEDIMENT ; PLASTICIZERS ; TDCPP ; EXPOSURE ; CARBAMAZEPINE ; INVOLVEMENT ; METABOLISM
PublisherAMER CHEMICAL SOC
Funding OrganizationMajor International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; Major International Joint Research Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36833
Collection中科院水生所知识产出(2009年前)
Corresponding AuthorZha, Jinmiao
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing Key Lab Ind Wastewater Treatment & Reuse, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100085, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Yan, Saihong,Wang, Qi,Yang, Lihua,et al. Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(11):6850-6858.
APA Yan, Saihong,Wang, Qi,Yang, Lihua,&Zha, Jinmiao.(2020).Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea).ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(11),6850-6858.
MLA Yan, Saihong,et al."Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.11(2020):6850-6858.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yan, Saihong]'s Articles
[Wang, Qi]'s Articles
[Yang, Lihua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yan, Saihong]'s Articles
[Wang, Qi]'s Articles
[Yang, Lihua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yan, Saihong]'s Articles
[Wang, Qi]'s Articles
[Yang, Lihua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.