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Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus)
Shi, Lixia1,2,3,4; Hu, Xudong1,2; Wang, Nenghan1,2; Liang, Huifang5; Wu, Chenxi1; Cao, Hong1,3
Corresponding AuthorCao, Hong(regancao@ihb.ac.cn)
2020-05-08
Source PublicationECOTOXICOLOGY
ISSN0963-9292
Pages12
AbstractArsenic is ubiquitously present in the aquatic environment. We investigated the acute toxic effects of arsenite [As(III)] exposure on rare minnows (Gobiocypris rarus) in vivo. The 96-h LC50 value for exposure to As(III) was 13.73 mg/L. As(III) bioaccumulation in different tissues was measured using inductively-coupled plasma mass spectrometry, and the extent of As(III) accumulation was, from greatest to least, liver > intestine > gills > muscle > kidney > testis > brain. Histological examination revealed that in As(III)-treated fish, numerous cellular and tissue alterations were present in the gill, liver, and intestine tissues. Moreover, transmission electron microscopy showed ultrastructural alterations in hepatocytes. We also performed transcriptome analyses to investigate As(III)-induced toxicity response in the liver of As(III)-treated fish; various oxidative-related genes were differentially expressed, and their expression levels were further validated using qPCR. This study is one of the many steps we aim to take on the way to promote the rare minnow to an international standard laboratory animal.
KeywordAcute arsenic toxicity Rare minnow Histopathology Mitochondria Transcriptome
DOI10.1007/s10646-020-02222-3
Funding OrganizationKey Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS
Indexed BySCI ; SCI
Language英语
Funding ProjectKey Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS[LFBC0903]
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEcology ; Environmental Sciences ; Toxicology
WOS IDWOS:000531129300002
WOS KeywordMITOCHONDRIAL PERMEABILITY TRANSITION ; FRESH-WATER FISH ; DRINKING-WATER ; LIVER-TISSUE ; GILL ; HEALTH ; BIOTRANSFORMATION ; IDENTIFICATION ; METABOLISM ; BIOMARKERS
PublisherSPRINGER
Funding OrganizationKey Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS ; Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, CAFS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36648
Collection水环境工程研究中心_期刊论文
Corresponding AuthorCao, Hong
Affiliation1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat Chinese Acad, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.CAFS, Key Lab Freshwater Biodivers Conservat, Yangtze River Fisheries Res Inst, Minist Agr & Rural Affairs, Wuhan 430223, Peoples R China
4.Huizhou Univ, Sch Life Sci, Huizhou 516007, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Peoples R China
Recommended Citation
GB/T 7714
Shi, Lixia,Hu, Xudong,Wang, Nenghan,et al. Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus)[J]. ECOTOXICOLOGY,2020:12.
APA Shi, Lixia,Hu, Xudong,Wang, Nenghan,Liang, Huifang,Wu, Chenxi,&Cao, Hong.(2020).Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus).ECOTOXICOLOGY,12.
MLA Shi, Lixia,et al."Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus)".ECOTOXICOLOGY (2020):12.
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