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Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae
Peng, Wei1,2; Liu, Sitian1,3; Guo, Yongyong1; Yang, Lihua1; Zhou, Bingsheng1
Corresponding AuthorYang, Lihua(lhyang@ihb.ac.cn)
2020-04-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume259Pages:9
AbstractThe emerging flame retardants pentabromobenzene (PBB) has been frequently detected in recent years and may pose exposure risks to wild animals and human beings. In this study, the inflation of posterior swim bladder of zebrafish larvae was used as an endpoint to study the developmental toxicity and putative mechanisms associated with PBB toxicity. Our results showed that embryonic exposure to PBB could significantly inhibit the inflation of posterior swim bladders. Reduced T3 levels and transcriptional changes of crh and pomc were observed in PBB treated zebrafish larvae at 120 hpf. However, key regulators of thyroid and adrenocortical system involved in the synthesis (tsh), biological conversion (ugt1ab, dio2) and functional regulation (tr alpha, tr beta, gr) showed no significant changes. Further data revealed that prlra was the only gene that was altered among the detected genes at 96 h post fertilization (hpf). At 120 hpf, the morphology of swim bladder indicated deflation in treatments at 0.25 mu M and higher. In addition, the mRNA levels of anxa5, prlra, prlrb, atp1b2 and slc12a10 were all significantly changed at 120 hpf. Taken together, we suppose that embryonic exposure to PBB inhibited the inflation of swim bladder in zebrafish probably via prlra mediated pathways. The observed changes of thyroid and adrenocortical parameters might be indirect effects evoked by PBB exposure. Overall, our results provide important data and indications for future toxicological study and risk assessment of the emerging flame retardants PBB. (C) 2020 Elsevier Ltd. All rights reserved.
KeywordPentabromobenzene Swim bladder inflation PRLR Zebrafish
DOI10.1016/j.envpol.2020.113923
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21737005] ; National Natural Science Foundation of China[31802277] ; National Science and Technology BasicWork of China[2014FY120200]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000528534600061
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; VACUOLAR-TYPE ATPASE ; FLAME RETARDANTS ; PROLACTIN RECEPTORS ; TISSUE DISTRIBUTION ; FRESH-WATER ; SWIMBLADDER ; EXPRESSION ; INNERVATION ; SEDIMENT
PublisherELSEVIER SCI LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China ; National Science and Technology BasicWork of China
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36642
Collection水环境工程研究中心_期刊论文
Corresponding AuthorYang, Lihua
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Hunan Univ Arts & Sci, Coll Life & Environm Sci, Changde 415000, Hunan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Peng, Wei,Liu, Sitian,Guo, Yongyong,et al. Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae[J]. ENVIRONMENTAL POLLUTION,2020,259:9.
APA Peng, Wei,Liu, Sitian,Guo, Yongyong,Yang, Lihua,&Zhou, Bingsheng.(2020).Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae.ENVIRONMENTAL POLLUTION,259,9.
MLA Peng, Wei,et al."Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae".ENVIRONMENTAL POLLUTION 259(2020):9.
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