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Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses
Ouyang, Gang1,2,3,4,5; Liao, Qian1,2,3,4,5; Zhang, Dawei1,2,3,4,5; Rong, Fangjing1,2,3,4,5; Cai, Xiaolian1,2,3,4,5; Fan, Sijia1,2,3,4,5; Zhu, Junji1,2,3,4,5; Wang, Jing1,2,3,4,5; Liu, Xing1,2,3,4,5; Liu, Xueqin6; Xiao, Wuhan1,2,3,4,5
Corresponding AuthorXiao, Wuhan(w-xiao@ihb.ac.cn)
2020-06-01
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume204Issue:11Pages:3019-3029
AbstractTranscriptional programs regulated by the NF-kappa B family are essential for the inflammatory response as well as for innate and adaptive immunity. NF-kappa B activation occurs via two major signaling pathways: the canonical and the noncanonical. The canonical NF-kappa B pathway responds to diverse immune stimulations and leads to rapid but transient activation. As a member of the canonical NF-kappa B family, p65 is thought to be a key regulator of viral infection. Because of the embryonic lethality of p65-null mice, the physiological role of p65 in the antiviral immune response is still unclear. In this study, we generated p65-null zebrafish, which were viable and indistinguishable from their wildtype (WT) siblings under normal conditions. However, p65-null zebrafish were more sensitive to spring viremia of carp virus infection than their WT siblings. Further assays indicated that proinflammatory and antiviral genes, including IFN, were downregulated in p65-null zebrafish after spring viremia of carp virus infection compared with their WT siblings. Our results thus suggested that p65 is required for the antiviral response, activating not only proinflammatory genes but also antiviral genes (including IFN).
DOI10.4049/jimmunol.1900309
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31671315] ; National Key R&D Program of China[2018YFA0801000] ; National Key R&D Program of China[2018YFD0900602] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000534598700015
WOS KeywordNF-KAPPA-B ; MESSENGER-RNA DECAY ; SPRING VIREMIA ; RELA ; FISH ; IMMUNITY ; RESCUES ; MICE ; P65
PublisherAMER ASSOC IMMUNOLOGISTS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36519
Collection水环境工程研究中心_期刊论文
Corresponding AuthorXiao, Wuhan
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
4.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Ouyang, Gang,Liao, Qian,Zhang, Dawei,et al. Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses[J]. JOURNAL OF IMMUNOLOGY,2020,204(11):3019-3029.
APA Ouyang, Gang.,Liao, Qian.,Zhang, Dawei.,Rong, Fangjing.,Cai, Xiaolian.,...&Xiao, Wuhan.(2020).Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses.JOURNAL OF IMMUNOLOGY,204(11),3019-3029.
MLA Ouyang, Gang,et al."Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses".JOURNAL OF IMMUNOLOGY 204.11(2020):3019-3029.
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