| Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses | |
| Ouyang, Gang1,2,3,4,5; Liao, Qian1,2,3,4,5; Zhang, Dawei1,2,3,4,5; Rong, Fangjing1,2,3,4,5; Cai, Xiaolian1,2,3,4,5; Fan, Sijia1,2,3,4,5; Zhu, Junji1,2,3,4,5; Wang, Jing1,2,3,4,5; Liu, Xing1,2,3,4,5; Liu, Xueqin6; Xiao, Wuhan1,2,3,4,5 | |
| Corresponding Author | Xiao, Wuhan(w-xiao@ihb.ac.cn) |
| 2020-06-01 | |
| Source Publication | JOURNAL OF IMMUNOLOGY
 |
| ISSN | 0022-1767 |
| Volume | 204Issue:11Pages:3019-3029 |
| Abstract | Transcriptional programs regulated by the NF-kappa B family are essential for the inflammatory response as well as for innate and adaptive immunity. NF-kappa B activation occurs via two major signaling pathways: the canonical and the noncanonical. The canonical NF-kappa B pathway responds to diverse immune stimulations and leads to rapid but transient activation. As a member of the canonical NF-kappa B family, p65 is thought to be a key regulator of viral infection. Because of the embryonic lethality of p65-null mice, the physiological role of p65 in the antiviral immune response is still unclear. In this study, we generated p65-null zebrafish, which were viable and indistinguishable from their wildtype (WT) siblings under normal conditions. However, p65-null zebrafish were more sensitive to spring viremia of carp virus infection than their WT siblings. Further assays indicated that proinflammatory and antiviral genes, including IFN, were downregulated in p65-null zebrafish after spring viremia of carp virus infection compared with their WT siblings. Our results thus suggested that p65 is required for the antiviral response, activating not only proinflammatory genes but also antiviral genes (including IFN). |
| DOI | 10.4049/jimmunol.1900309 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31671315] ; National Key R&D Program of China[2018YFA0801000] ; National Key R&D Program of China[2018YFD0900602] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308] |
| WOS Research Area | Immunology |
| WOS Subject | Immunology |
| WOS ID | WOS:000534598700015 |
| WOS Keyword | NF-KAPPA-B ; MESSENGER-RNA DECAY ; SPRING VIREMIA ; RELA ; FISH ; IMMUNITY ; RESCUES ; MICE ; P65 |
| Publisher | AMER ASSOC IMMUNOLOGISTS |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/36519 |
| Collection | 水环境工程研究中心_期刊论文 |
| Corresponding Author | Xiao, Wuhan |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 4.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China |
| Recommended Citation GB/T 7714 | Ouyang, Gang,Liao, Qian,Zhang, Dawei,et al. Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses[J]. JOURNAL OF IMMUNOLOGY,2020,204(11):3019-3029. |
| APA | Ouyang, Gang.,Liao, Qian.,Zhang, Dawei.,Rong, Fangjing.,Cai, Xiaolian.,...&Xiao, Wuhan.(2020).Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses.JOURNAL OF IMMUNOLOGY,204(11),3019-3029. |
| MLA | Ouyang, Gang,et al."Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses".JOURNAL OF IMMUNOLOGY 204.11(2020):3019-3029. |
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