IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA
Hou, Jing1,2,3,4,5; Chen, Shan Nan1,2; Gan, Zhen1,2; Li, Nan1,2; Huang, Lin1,2; Huo, Hui Jun1,2; Yang, Yue Cong1,2; Lu, Yishan4,5; Yin, Zhan1,2; Nie, Pin1,2,6,7
Corresponding AuthorNie, Pin(pinnie@ihb.ac.cn)
2020-05-01
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume204Issue:9Pages:2401-2415
AbstractMammalian CIITA isoforms are tightly regulated by independent promoters. These promotors are induced by IFN-g through JAK-STAT signaling pathway. The induction of CIITA controls the expression of MHC class II (MHCII) and Ag presentation to the adaptive immune system. In the current study, to our knowledge, we first identified two independent promoters, p1 and p2, in the zebrafish ( Danio rerio) that control the expression of the two variants of CIITA, CIITA variant 1 (CIITAv1), and CIITA variant 2 (CIITAv2), respectively. Moreover, although IRF1 in an IFN-gamma signaling pathway induced CIITAv2, which has two ISRE motifs in its promoter, CIITAv1 expression was not induced by this signal. Further, the transcription of MHCII DAB was controlled by IRF1 via two distinct mechanisms: 1) the transcription of MHCII DAB was controlled by IRF1 indirectly through the two ISREs in p2; and 2) directly via the ISRE in MHCII DAB promoter. We also found that IRF1 associated with CIITAv1 and CIITAv2 via protein-protein interactions to synergistically drive the transcription of MHCII DAB. The IFN-gamma-IRF1-CIITA-MHCII signaling cascade was functional in early life stages of CIITA(-/-) and IRF1(-/-) zebrafish. Our findings imply that the immune system develops early in fishes and that the IFN-g signaling cascade-induced CIITA and MHCII DAB is conserved in teleost fishes and mammals.
DOI10.4049/jimmunol.1801480
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31320103913] ; China Agriculture Research System[CARS46] ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China[(2018)8] ; First class fishery discipline program in Shandong Province, China[(2018)27]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000528255900009
WOS KeywordOPEN READING FRAMES ; BARE LYMPHOCYTE SYNDROME ; MICE LACKING ; TRANSCRIPTION FACTORS ; MOLECULAR-MECHANISMS ; EARLY MACROPHAGES ; PROMOTER ; GENES ; UPSTREAM ; ACTIVATION
PublisherAMER ASSOC IMMUNOLOGISTS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36408
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorNie, Pin
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquaculture Dis Control, Wuhan 430072, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Guangdong, Peoples R China
5.Guangdong Ocean Univ, Coll Fisheries, Prov Key Lab Pathogen Biol & Epidemiol Aquat Anim, Zhanjiang 524088, Guangdong, Peoples R China
6.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
7.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Hou, Jing,Chen, Shan Nan,Gan, Zhen,et al. In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA[J]. JOURNAL OF IMMUNOLOGY,2020,204(9):2401-2415.
APA Hou, Jing.,Chen, Shan Nan.,Gan, Zhen.,Li, Nan.,Huang, Lin.,...&Nie, Pin.(2020).In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA.JOURNAL OF IMMUNOLOGY,204(9),2401-2415.
MLA Hou, Jing,et al."In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA".JOURNAL OF IMMUNOLOGY 204.9(2020):2401-2415.
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