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Sex-dependent and organ-specific toxicity of silver nanoparticles in livers and intestines of adult zebrafish
Bao, Shaopan1; Tang, Wei1; Fang, Tao1,2
Corresponding AuthorFang, Tao(fangt@ihb.ac.cn)
2020-06-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume249Pages:9
AbstractSilver nanoparticles (AgNPs) have been increasingly manufactured and thus are increasingly detected in aquatic systems. However, there are still some overlooked factors (e.g., organism sex) in the field of nanotoxicological assessment. In this study, to explore the role of sex in nanotoxicity, adult male and female zebrafish were exposed to 100 mu g/L of two uncoated commercial AgNPs with primary sizes 20 nm and 80 nm for 2 weeks, after which the impacts of AgNPs on intestines and livers of both male and female zebrafish were assessed using a suite of biomarkers. Results demonstrated that the intestinal Na/KATPase activity as well as the superoxide dismutase activity in male zebrafish differed significantly between 20-nm AgNPs and 80-nm AgNPs treatments (p < 0.05), indicating 20-nm AgNPs showing higher toxicity to zebrafish than the 80-nm AgNPs. Also, we noted that the used AgNPs induced sex-dependent effects on growth indices, oxidative/anti-oxidative status, neural signaling and hepatic lipid metabolism, with the male zebrafish being more sensitive to AgNPs than the females. Further, the tested AgNPs impaired the intestine much more seriously than the liver, as evidenced by the disruptions of Na/KATPase and antioxidant system in intestine but not in liver. These findings imply that prolonged exposure to AgNPs might induce size-related, sex-dependent, and organ-specific toxicity to adult zebrafish, thereby may significantly extend our understanding of the toxic effects of AgNPs in aquatic environment. (C) 2020 Elsevier Ltd. All rights reserved.
KeywordOxidative stress Neural signaling Lipid metabolism Size Aquatic environment
DOI10.1016/j.chemosphere.2020.126172
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41907324] ; National Key R&D Program of China[2018YFD0900801]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000527935600072
WOS KeywordTITANIUM-DIOXIDE NANOPARTICLES ; SIZE-CONTROLLED DISSOLUTION ; CARP CYPRINUS-CARPIO ; OXIDATIVE STRESS ; ENVIRONMENTAL EMISSIONS ; ONCORHYNCHUS-MYKISS ; TISSUE DISTRIBUTION ; RAINBOW-TROUT ; IONIC SILVER ; DANIO-RERIO
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/36405
Collection水环境工程研究中心_期刊论文
Corresponding AuthorFang, Tao
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, 7 Donghu South Rd, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Bao, Shaopan,Tang, Wei,Fang, Tao. Sex-dependent and organ-specific toxicity of silver nanoparticles in livers and intestines of adult zebrafish[J]. CHEMOSPHERE,2020,249:9.
APA Bao, Shaopan,Tang, Wei,&Fang, Tao.(2020).Sex-dependent and organ-specific toxicity of silver nanoparticles in livers and intestines of adult zebrafish.CHEMOSPHERE,249,9.
MLA Bao, Shaopan,et al."Sex-dependent and organ-specific toxicity of silver nanoparticles in livers and intestines of adult zebrafish".CHEMOSPHERE 249(2020):9.
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